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# BioPerl module for Bio::Ontology::SimpleOntologyEngine |
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# |
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# Please direct questions and support issues to |
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# |
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# Cared for by Peter Dimitrov |
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# |
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# Copyright Peter Dimitrov |
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# (c) Peter Dimitrov, dimitrov@gnf.org, 2002. |
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# (c) GNF, Genomics Institute of the Novartis Research Foundation, 2002. |
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# |
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# You may distribute this module under the same terms as perl itself. |
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# Refer to the Perl Artistic License (see the license accompanying this |
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# software package, or see http://www.perl.com/language/misc/Artistic.html) |
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# for the terms under which you may use, modify, and redistribute this module. |
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# |
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# THIS PACKAGE IS PROVIDED "AS IS" AND WITHOUT ANY EXPRESS OR IMPLIED |
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# WARRANTIES, INCLUDING, WITHOUT LIMITATION, THE IMPLIED WARRANTIES OF |
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# MERCHANTIBILITY AND FITNESS FOR A PARTICULAR PURPOSE. |
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# |
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# POD documentation - main docs before the code |
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=head1 NAME |
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Bio::Ontology::SimpleOntologyEngine - Implementation of OntologyEngineI interface |
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=head1 SYNOPSIS |
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my $soe = Bio::Ontology::SimpleOntologyEngine->new; |
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=head1 DESCRIPTION |
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This is a "simple" implementation of Bio::Ontology::OntologyEngineI. |
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=head1 FEEDBACK |
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=head2 Mailing Lists |
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User feedback is an integral part of the evolution of this and other |
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Bioperl modules. Send your comments and suggestions preferably to |
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the Bioperl mailing list. Your participation is much appreciated. |
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bioperl-l@bioperl.org - General discussion |
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http://bioperl.org/wiki/Mailing_lists - About the mailing lists |
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=head2 Support |
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Please direct usage questions or support issues to the mailing list: |
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I |
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rather than to the module maintainer directly. Many experienced and |
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reponsive experts will be able look at the problem and quickly |
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address it. Please include a thorough description of the problem |
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with code and data examples if at all possible. |
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=head2 Reporting Bugs |
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Report bugs to the Bioperl bug tracking system to help us keep track |
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of the bugs and their resolution. Bug reports can be submitted via |
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the web: |
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https://github.com/bioperl/bioperl-live/issues |
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=head1 AUTHOR - Peter Dimitrov |
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Email dimitrov@gnf.org |
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=head1 CONTRIBUTORS |
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Hilmar Lapp, hlapp at gmx.net |
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=head1 APPENDIX |
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The rest of the documentation details each of the object methods. |
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Internal methods are usually preceded with a _ |
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=cut |
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# Let the code begin... |
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package Bio::Ontology::SimpleOntologyEngine; |
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use strict; |
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use Carp; |
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use Bio::Ontology::RelationshipFactory; |
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use Data::Dumper; |
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use base qw(Bio::Root::Root Bio::Ontology::OntologyEngineI); |
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=head2 new |
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Title : new |
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Usage : $soe = Bio::Ontology::SimpleOntologyEngine->new; |
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Function: Initializes the ontology engine. |
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Example : $soe = Bio::Ontology::SimpleOntologyEngine->new; |
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Returns : Object of class SimpleOntologyEngine. |
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Args : |
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=cut |
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sub new { |
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my ( $class, @args ) = @_; |
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my $self = $class->SUPER::new(@args); |
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# my %param = @args; |
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$self->_term_store( {} ); |
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$self->_relationship_store( {} ); |
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$self->_inverted_relationship_store( {} ); |
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$self->_relationship_type_store( {} ); |
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$self->_instantiated_terms_store( {} ); |
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# set defaults for the factories |
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$self->relationship_factory( |
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Bio::Ontology::RelationshipFactory->new( -type => "Bio::Ontology::Relationship" ) ); |
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return $self; |
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} |
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=head2 _instantiated_terms_store |
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Title : _instantiated_terms_store |
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Usage : $obj->_instantiated_terms_store($newval) |
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Function: |
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Example : |
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Returns : hash |
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Args : empty hash |
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=cut |
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sub _instantiated_terms_store { |
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my ( $self, $value ) = @_; |
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if ( defined $value ) { |
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$self->{'_instantiated_terms_store'} = $value; |
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} |
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return $self->{'_instantiated_terms_store'}; |
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} |
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=head2 mark_instantiated |
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Title : mark_instantiated |
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Usage : $self->mark_instantiated(TermI terms): TermI |
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Function: Marks TermI objects as fully instantiated, |
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allowing for proper counting of the number of terms in the term store. |
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The TermI objects has to be already stored in the term store in order |
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to be marked. |
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Example : $self->mark_instantiated($term); |
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Returns : its argument or throws an exception if a term is not |
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in the term store. |
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Args : array of objects of class TermI. |
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=cut |
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sub mark_instantiated { |
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my ( $self, @terms ) = @_; |
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foreach my $term (@terms) { |
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$self->throw( "term " . $term->identifier . " not in the term store\n" ) |
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if !defined $self->_term_store->{ $term->identifier }; |
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$self->_instantiated_terms_store->{ $term->identifier } = 1; |
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} |
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return @terms; |
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} |
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=head2 mark_uninstantiated |
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Title : mark_uninstantiated |
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Usage : $self->mark_uninstantiated(TermI terms): TermI |
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Function: Marks TermI objects as not fully instantiated, |
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Example : $self->mark_uninstantiated($term); |
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Returns : its argument or throws an exception if a term is not |
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in the term store(if the term is not marked it does nothing). |
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Args : array of objects of class TermI. |
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=cut |
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sub mark_uninstantiated { |
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my ( $self, @terms ) = @_; |
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foreach my $term (@terms) { |
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$self->throw( "term " . $term->identifier . " not in the term store\n" ) |
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if !defined $self->_term_store->{ $term->identifier }; |
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delete $self->_instantiated_terms_store->{ $term->identifier } |
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if defined $self->_instantiated_terms_store->{ $term->identifier }; |
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} |
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return @terms; |
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} |
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=head2 _term_store |
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193
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Title : term_store |
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Usage : $obj->_term_store($newval) |
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Function: |
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Example : |
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Returns : reference to an array of Bio::Ontology::TermI objects |
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Args : reference to an array of Bio::Ontology::TermI objects |
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200
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=cut |
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202
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sub _term_store { |
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my ( $self, $value ) = @_; |
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205
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if ( defined $value ) { |
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1
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6
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if ( defined $self->{'_term_store'} ) { |
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0
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0
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$self->throw("_term_store already defined\n"); |
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} else { |
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1
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2
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$self->{'_term_store'} = $value; |
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210
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} |
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211
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} |
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212
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213
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28
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38
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return $self->{'_term_store'}; |
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214
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} |
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215
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216
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=head2 add_term |
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217
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218
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Title : add_term |
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219
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Usage : add_term(TermI term): TermI |
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220
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Function: Adds TermI object to the ontology engine term store. |
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221
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Marks the term fully instantiated by default. |
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222
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Example : $soe->add_term($term) |
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223
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Returns : its argument. |
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224
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Args : object of class TermI. |
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225
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226
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=cut |
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227
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228
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sub add_term { |
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229
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4
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4
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1
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6
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my ( $self, $term ) = @_; |
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230
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4
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6
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my $term_store = $self->_term_store; |
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231
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232
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4
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50
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33
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8
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if ( defined $term_store->{ $term->identifier } && $self->_instantiated_terms_store->{ $term->identifier }) { |
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233
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0
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0
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$self->throw( "term " . $term->identifier . " already defined\n" ); |
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234
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} else { |
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235
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4
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6
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$term_store->{ $term->identifier } = $term; |
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236
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4
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8
|
$self->_instantiated_terms_store->{ $term->identifier } = 1; |
|
237
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} |
|
238
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239
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4
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|
9
|
return $term; |
|
240
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} |
|
241
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242
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|
=head2 get_term_by_identifier |
|
243
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244
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|
Title : get_term_by_identifier |
|
245
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|
|
Usage : get_term_by_identifier(String id): TermI |
|
246
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|
Function: Retrieves terms from the term store by their identifier |
|
247
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|
|
field, or an empty list if not there. |
|
248
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|
Example : $term = $soe->get_term_by_identifier("IPR000001"); |
|
249
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|
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|
|
Returns : An array of zero or more Bio::Ontology::TermI objects. |
|
250
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|
|
Args : An array of identifier strings |
|
251
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|
252
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|
=cut |
|
253
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|
254
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|
|
sub get_term_by_identifier { |
|
255
|
10
|
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|
10
|
1
|
18
|
my ( $self, @ids ) = @_; |
|
256
|
10
|
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|
11
|
my @ans = (); |
|
257
|
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|
258
|
10
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|
12
|
foreach my $id (@ids) { |
|
259
|
21
|
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|
27
|
my $term = $self->_term_store->{$id}; |
|
260
|
21
|
50
|
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|
35
|
push @ans, $term if defined $term; |
|
261
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|
|
} |
|
262
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|
263
|
10
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|
22
|
return @ans; |
|
264
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|
} |
|
265
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|
266
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|
|
=head2 _get_number_rels |
|
267
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|
268
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|
|
|
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|
|
Title : get_number_rels |
|
269
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|
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|
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|
|
Usage : |
|
270
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|
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|
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|
|
Function: |
|
271
|
|
|
|
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|
|
Example : |
|
272
|
|
|
|
|
|
|
Returns : |
|
273
|
|
|
|
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|
|
Args : |
|
274
|
|
|
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|
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|
275
|
|
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|
|
|
|
=cut |
|
276
|
|
|
|
|
|
|
|
|
277
|
|
|
|
|
|
|
sub _get_number_rels { |
|
278
|
0
|
|
|
0
|
|
0
|
my ($self) = @_; |
|
279
|
0
|
|
|
|
|
0
|
my $num_rels = 0; |
|
280
|
|
|
|
|
|
|
|
|
281
|
0
|
|
|
|
|
0
|
foreach my $entry ( $self->_relationship_store ) { |
|
282
|
0
|
|
|
|
|
0
|
$num_rels += scalar keys %$entry; |
|
283
|
|
|
|
|
|
|
} |
|
284
|
0
|
|
|
|
|
0
|
return $num_rels; |
|
285
|
|
|
|
|
|
|
} |
|
286
|
|
|
|
|
|
|
|
|
287
|
|
|
|
|
|
|
=head2 _get_number_terms |
|
288
|
|
|
|
|
|
|
|
|
289
|
|
|
|
|
|
|
Title : _get_number_terms |
|
290
|
|
|
|
|
|
|
Usage : |
|
291
|
|
|
|
|
|
|
Function: |
|
292
|
|
|
|
|
|
|
Example : |
|
293
|
|
|
|
|
|
|
Returns : |
|
294
|
|
|
|
|
|
|
Args : |
|
295
|
|
|
|
|
|
|
|
|
296
|
|
|
|
|
|
|
=cut |
|
297
|
|
|
|
|
|
|
|
|
298
|
|
|
|
|
|
|
sub _get_number_terms { |
|
299
|
0
|
|
|
0
|
|
0
|
my ($self) = @_; |
|
300
|
|
|
|
|
|
|
|
|
301
|
0
|
|
|
|
|
0
|
return scalar $self->_filter_unmarked( values %{ $self->_term_store } ); |
|
|
0
|
|
|
|
|
0
|
|
|
302
|
|
|
|
|
|
|
|
|
303
|
|
|
|
|
|
|
} |
|
304
|
|
|
|
|
|
|
|
|
305
|
|
|
|
|
|
|
=head2 _relationship_store |
|
306
|
|
|
|
|
|
|
|
|
307
|
|
|
|
|
|
|
Title : _storerelationship_store |
|
308
|
|
|
|
|
|
|
Usage : $obj->relationship_store($newval) |
|
309
|
|
|
|
|
|
|
Function: |
|
310
|
|
|
|
|
|
|
Example : |
|
311
|
|
|
|
|
|
|
Returns : reference to an array of Bio::Ontology::TermI objects |
|
312
|
|
|
|
|
|
|
Args : reference to an array of Bio::Ontology::TermI objects |
|
313
|
|
|
|
|
|
|
|
|
314
|
|
|
|
|
|
|
=cut |
|
315
|
|
|
|
|
|
|
|
|
316
|
|
|
|
|
|
|
sub _relationship_store { |
|
317
|
19
|
|
|
19
|
|
28
|
my ( $self, $value ) = @_; |
|
318
|
|
|
|
|
|
|
|
|
319
|
19
|
100
|
|
|
|
32
|
if ( defined $value ) { |
|
320
|
1
|
50
|
|
|
|
3
|
if ( defined $self->{'_relationship_store'} ) { |
|
321
|
0
|
|
|
|
|
0
|
$self->throw("_relationship_store already defined\n"); |
|
322
|
|
|
|
|
|
|
} else { |
|
323
|
1
|
|
|
|
|
2
|
$self->{'_relationship_store'} = $value; |
|
324
|
|
|
|
|
|
|
} |
|
325
|
|
|
|
|
|
|
} |
|
326
|
|
|
|
|
|
|
|
|
327
|
19
|
|
|
|
|
43
|
return $self->{'_relationship_store'}; |
|
328
|
|
|
|
|
|
|
} |
|
329
|
|
|
|
|
|
|
|
|
330
|
|
|
|
|
|
|
=head2 _inverted_relationship_store |
|
331
|
|
|
|
|
|
|
|
|
332
|
|
|
|
|
|
|
Title : _inverted_relationship_store |
|
333
|
|
|
|
|
|
|
Usage : |
|
334
|
|
|
|
|
|
|
Function: |
|
335
|
|
|
|
|
|
|
Example : |
|
336
|
|
|
|
|
|
|
Returns : reference to an array of Bio::Ontology::TermI objects |
|
337
|
|
|
|
|
|
|
Args : reference to an array of Bio::Ontology::TermI objects |
|
338
|
|
|
|
|
|
|
|
|
339
|
|
|
|
|
|
|
=cut |
|
340
|
|
|
|
|
|
|
|
|
341
|
|
|
|
|
|
|
sub _inverted_relationship_store { |
|
342
|
13
|
|
|
13
|
|
17
|
my ( $self, $value ) = @_; |
|
343
|
|
|
|
|
|
|
|
|
344
|
13
|
100
|
|
|
|
20
|
if ( defined $value ) { |
|
345
|
1
|
50
|
|
|
|
2
|
if ( defined $self->{'_inverted_relationship_store'} ) { |
|
346
|
0
|
|
|
|
|
0
|
$self->throw("_inverted_relationship_store already defined\n"); |
|
347
|
|
|
|
|
|
|
} else { |
|
348
|
1
|
|
|
|
|
2
|
$self->{'_inverted_relationship_store'} = $value; |
|
349
|
|
|
|
|
|
|
} |
|
350
|
|
|
|
|
|
|
} |
|
351
|
|
|
|
|
|
|
|
|
352
|
13
|
|
|
|
|
24
|
return $self->{'_inverted_relationship_store'}; |
|
353
|
|
|
|
|
|
|
} |
|
354
|
|
|
|
|
|
|
|
|
355
|
|
|
|
|
|
|
=head2 _relationship_type_store |
|
356
|
|
|
|
|
|
|
|
|
357
|
|
|
|
|
|
|
Title : _relationship_type_store |
|
358
|
|
|
|
|
|
|
Usage : $obj->_relationship_type_store($newval) |
|
359
|
|
|
|
|
|
|
Function: |
|
360
|
|
|
|
|
|
|
Example : |
|
361
|
|
|
|
|
|
|
Returns : reference to an array of Bio::Ontology::RelationshipType objects |
|
362
|
|
|
|
|
|
|
Args : reference to an array of Bio::Ontology::RelationshipType objects |
|
363
|
|
|
|
|
|
|
|
|
364
|
|
|
|
|
|
|
=cut |
|
365
|
|
|
|
|
|
|
|
|
366
|
|
|
|
|
|
|
sub _relationship_type_store { |
|
367
|
5
|
|
|
5
|
|
6
|
my ( $self, $value ) = @_; |
|
368
|
|
|
|
|
|
|
|
|
369
|
5
|
100
|
|
|
|
8
|
if ( defined $value ) { |
|
370
|
1
|
50
|
|
|
|
2
|
if ( defined $self->{'_relationship_type_store'} ) { |
|
371
|
0
|
|
|
|
|
0
|
$self->throw("_relationship_type_store already defined\n"); |
|
372
|
|
|
|
|
|
|
} else { |
|
373
|
1
|
|
|
|
|
2
|
$self->{'_relationship_type_store'} = $value; |
|
374
|
|
|
|
|
|
|
} |
|
375
|
|
|
|
|
|
|
} |
|
376
|
|
|
|
|
|
|
|
|
377
|
5
|
|
|
|
|
9
|
return $self->{'_relationship_type_store'}; |
|
378
|
|
|
|
|
|
|
} |
|
379
|
|
|
|
|
|
|
|
|
380
|
|
|
|
|
|
|
=head2 _add_relationship_simple |
|
381
|
|
|
|
|
|
|
|
|
382
|
|
|
|
|
|
|
Title : _add_relationship_simple |
|
383
|
|
|
|
|
|
|
Usage : |
|
384
|
|
|
|
|
|
|
Function: |
|
385
|
|
|
|
|
|
|
Example : |
|
386
|
|
|
|
|
|
|
Returns : |
|
387
|
|
|
|
|
|
|
Args : |
|
388
|
|
|
|
|
|
|
|
|
389
|
|
|
|
|
|
|
=cut |
|
390
|
|
|
|
|
|
|
|
|
391
|
|
|
|
|
|
|
sub _add_relationship_simple { |
|
392
|
12
|
|
|
12
|
|
16
|
my ( $self, $store, $rel, $inverted ) = @_; |
|
393
|
|
|
|
|
|
|
|
|
394
|
12
|
100
|
|
|
|
21
|
my $subject = $rel->subject_term |
|
395
|
|
|
|
|
|
|
or $self->throw('cannot add relationship, relationship has no subject_term'); |
|
396
|
10
|
100
|
|
|
|
17
|
my $object = $rel->object_term |
|
397
|
|
|
|
|
|
|
or $self->throw('cannot add relationship, relationship has no object_term'); |
|
398
|
|
|
|
|
|
|
|
|
399
|
8
|
|
|
|
|
12
|
my ( $parent_id, $child_id ) = ( $object->identifier, $subject->identifier ); |
|
400
|
8
|
100
|
|
|
|
16
|
( $parent_id, $child_id ) = ( $child_id, $parent_id ) if $inverted; |
|
401
|
|
|
|
|
|
|
|
|
402
|
8
|
50
|
66
|
|
|
19
|
if ( defined $store->{$parent_id} |
|
|
|
|
33
|
|
|
|
|
|
403
|
|
|
|
|
|
|
&& defined $store->{$parent_id}->{$child_id} |
|
404
|
|
|
|
|
|
|
&& $store->{$parent_id}->{$child_id}->name ne $rel->predicate_term->name |
|
405
|
|
|
|
|
|
|
) { |
|
406
|
|
|
|
|
|
|
$self->throw( "relationship " |
|
407
|
|
|
|
|
|
|
. $rel->predicate_term->name |
|
408
|
|
|
|
|
|
|
. " between " |
|
409
|
|
|
|
|
|
|
. $parent_id . " and " |
|
410
|
|
|
|
|
|
|
. $child_id |
|
411
|
|
|
|
|
|
|
. " already defined as " |
|
412
|
0
|
|
|
|
|
0
|
. $store->{$parent_id}->{$child_id}->name |
|
413
|
|
|
|
|
|
|
. "\n" ); |
|
414
|
|
|
|
|
|
|
} |
|
415
|
|
|
|
|
|
|
|
|
416
|
|
|
|
|
|
|
# all is well if we get here |
|
417
|
8
|
|
|
|
|
13
|
$store->{$parent_id}->{$child_id} = $rel->predicate_term; |
|
418
|
|
|
|
|
|
|
} |
|
419
|
|
|
|
|
|
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|
420
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=head2 add_relationship |
|
421
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422
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Title : add_relationship |
|
423
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|
|
Usage : add_relationship(RelationshipI relationship): RelationshipI |
|
424
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|
|
Function: Adds a relationship object to the ontology engine. |
|
425
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Example : |
|
426
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Returns : Its argument. |
|
427
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Args : A RelationshipI object. |
|
428
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429
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=cut |
|
430
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|
431
|
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|
sub add_relationship { |
|
432
|
8
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|
8
|
1
|
12
|
my ( $self, $rel ) = @_; |
|
433
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|
434
|
8
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14
|
$self->_add_relationship_simple( $self->_relationship_store, $rel, 0 ); |
|
435
|
4
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6
|
$self->_add_relationship_simple( $self->_inverted_relationship_store, $rel, 1 ); |
|
436
|
4
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7
|
$self->_relationship_type_store->{ $self->_unique_termid( $rel->predicate_term ) } = |
|
437
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$rel->predicate_term; |
|
438
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439
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4
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9
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return $rel; |
|
440
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} |
|
441
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442
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=head2 get_relationships |
|
443
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|
444
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|
Title : get_relationships |
|
445
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|
Usage : get_relationships(): RelationshipI |
|
446
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|
Function: Retrieves all relationship objects. |
|
447
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|
|
Example : |
|
448
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|
|
|
Returns : Array of RelationshipI objects |
|
449
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|
|
|
Args : |
|
450
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451
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|
=cut |
|
452
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|
453
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|
|
sub get_relationships { |
|
454
|
0
|
|
|
0
|
1
|
0
|
my $self = shift; |
|
455
|
0
|
|
|
|
|
0
|
my $term = shift; |
|
456
|
0
|
|
|
|
|
0
|
my @rels; |
|
457
|
0
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|
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|
|
0
|
my $store = $self->_relationship_store; |
|
458
|
0
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|
|
|
0
|
my $relfact = $self->relationship_factory(); |
|
459
|
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|
460
|
|
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|
|
|
my @parent_ids = $term |
|
461
|
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|
|
? |
|
462
|
|
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|
463
|
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|
|
# if a term is supplied then only get the term's parents |
|
464
|
0
|
|
|
|
|
0
|
( map { $_->identifier(); } $self->get_parent_terms($term) ) |
|
465
|
|
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|
|
: |
|
466
|
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|
|
467
|
|
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|
|
|
|
# otherwise use all parent ids |
|
468
|
0
|
0
|
|
|
|
0
|
( keys %{$store} ); |
|
|
0
|
|
|
|
|
0
|
|
|
469
|
|
|
|
|
|
|
|
|
470
|
|
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|
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|
|
# add the term as a parent too if one is supplied |
|
471
|
0
|
0
|
|
|
|
0
|
push( @parent_ids, $term->identifier ) if $term; |
|
472
|
|
|
|
|
|
|
|
|
473
|
0
|
|
|
|
|
0
|
foreach my $parent_id (@parent_ids) { |
|
474
|
0
|
|
|
|
|
0
|
my $parent_entry = $store->{$parent_id}; |
|
475
|
|
|
|
|
|
|
|
|
476
|
|
|
|
|
|
|
# if a term is supplied, add a relationship for the parent to the term |
|
477
|
|
|
|
|
|
|
# except if the parent is the term itself (we added that one before) |
|
478
|
0
|
0
|
0
|
|
|
0
|
if ( $term && ( $parent_id ne $term->identifier() ) ) { |
|
479
|
0
|
|
|
|
|
0
|
my @parent_terms = $self->get_term_by_identifier($parent_id); |
|
480
|
0
|
|
|
|
|
0
|
foreach my $parent_term (@parent_terms) { |
|
481
|
|
|
|
|
|
|
push( |
|
482
|
|
|
|
|
|
|
@rels, |
|
483
|
|
|
|
|
|
|
$relfact->create_object( |
|
484
|
|
|
|
|
|
|
-object_term => $parent_term, |
|
485
|
|
|
|
|
|
|
-subject_term => $term, |
|
486
|
0
|
|
|
|
|
0
|
-predicate_term => $parent_entry->{ $term->identifier }, |
|
487
|
|
|
|
|
|
|
-ontology => $term->ontology() |
|
488
|
|
|
|
|
|
|
) |
|
489
|
|
|
|
|
|
|
); |
|
490
|
|
|
|
|
|
|
} |
|
491
|
|
|
|
|
|
|
|
|
492
|
|
|
|
|
|
|
} else { |
|
493
|
|
|
|
|
|
|
|
|
494
|
|
|
|
|
|
|
# otherwise, i.e., no term supplied, or the parent equals the |
|
495
|
|
|
|
|
|
|
# supplied term |
|
496
|
0
|
0
|
|
|
|
0
|
my @parent_terms = $term ? ($term) : $self->get_term_by_identifier($parent_id); |
|
497
|
0
|
|
|
|
|
0
|
foreach my $child_id ( keys %$parent_entry ) { |
|
498
|
0
|
|
|
|
|
0
|
my $rel_info = $parent_entry->{$child_id}; |
|
499
|
0
|
|
|
|
|
0
|
my ($subj_term) = $self->get_term_by_identifier($child_id); |
|
500
|
|
|
|
|
|
|
|
|
501
|
0
|
|
|
|
|
0
|
foreach my $parent_term (@parent_terms) { |
|
502
|
0
|
|
|
|
|
0
|
push( |
|
503
|
|
|
|
|
|
|
@rels, |
|
504
|
|
|
|
|
|
|
$relfact->create_object( |
|
505
|
|
|
|
|
|
|
-object_term => $parent_term, |
|
506
|
|
|
|
|
|
|
-subject_term => $subj_term, |
|
507
|
|
|
|
|
|
|
-predicate_term => $rel_info, |
|
508
|
|
|
|
|
|
|
-ontology => $parent_term->ontology |
|
509
|
|
|
|
|
|
|
) |
|
510
|
|
|
|
|
|
|
); |
|
511
|
|
|
|
|
|
|
} |
|
512
|
|
|
|
|
|
|
} |
|
513
|
|
|
|
|
|
|
} |
|
514
|
|
|
|
|
|
|
} |
|
515
|
|
|
|
|
|
|
|
|
516
|
0
|
|
|
|
|
0
|
return @rels; |
|
517
|
|
|
|
|
|
|
} |
|
518
|
|
|
|
|
|
|
|
|
519
|
|
|
|
|
|
|
=head2 get_all_relationships |
|
520
|
|
|
|
|
|
|
|
|
521
|
|
|
|
|
|
|
Title : get_all_relationships |
|
522
|
|
|
|
|
|
|
Usage : get_all_relationships(): RelationshipI |
|
523
|
|
|
|
|
|
|
Function: Retrieves all relationship objects. |
|
524
|
|
|
|
|
|
|
Example : |
|
525
|
|
|
|
|
|
|
Returns : Array of RelationshipI objects |
|
526
|
|
|
|
|
|
|
Args : |
|
527
|
|
|
|
|
|
|
|
|
528
|
|
|
|
|
|
|
=cut |
|
529
|
|
|
|
|
|
|
|
|
530
|
|
|
|
|
|
|
sub get_all_relationships { |
|
531
|
0
|
|
|
0
|
1
|
0
|
return shift->get_relationships(); |
|
532
|
|
|
|
|
|
|
} |
|
533
|
|
|
|
|
|
|
|
|
534
|
|
|
|
|
|
|
=head2 get_predicate_terms |
|
535
|
|
|
|
|
|
|
|
|
536
|
|
|
|
|
|
|
Title : get_predicate_terms |
|
537
|
|
|
|
|
|
|
Usage : get_predicate_terms(): TermI |
|
538
|
|
|
|
|
|
|
Function: Retrieves all relationship types stored in the engine |
|
539
|
|
|
|
|
|
|
Example : |
|
540
|
|
|
|
|
|
|
Returns : reference to an array of Bio::Ontology::RelationshipType objects |
|
541
|
|
|
|
|
|
|
Args : |
|
542
|
|
|
|
|
|
|
|
|
543
|
|
|
|
|
|
|
=cut |
|
544
|
|
|
|
|
|
|
|
|
545
|
|
|
|
|
|
|
sub get_predicate_terms { |
|
546
|
0
|
|
|
0
|
1
|
0
|
my ($self) = @_; |
|
547
|
|
|
|
|
|
|
|
|
548
|
0
|
|
|
|
|
0
|
return values %{ $self->_relationship_type_store }; |
|
|
0
|
|
|
|
|
0
|
|
|
549
|
|
|
|
|
|
|
} |
|
550
|
|
|
|
|
|
|
|
|
551
|
|
|
|
|
|
|
=head2 _is_rel_type |
|
552
|
|
|
|
|
|
|
|
|
553
|
|
|
|
|
|
|
Title : _is_rel_type |
|
554
|
|
|
|
|
|
|
Usage : |
|
555
|
|
|
|
|
|
|
Function: |
|
556
|
|
|
|
|
|
|
Example : |
|
557
|
|
|
|
|
|
|
Returns : |
|
558
|
|
|
|
|
|
|
Args : |
|
559
|
|
|
|
|
|
|
|
|
560
|
|
|
|
|
|
|
=cut |
|
561
|
|
|
|
|
|
|
|
|
562
|
|
|
|
|
|
|
sub _is_rel_type { |
|
563
|
16
|
|
|
16
|
|
19
|
my ( $self, $term, @rel_types ) = @_; |
|
564
|
|
|
|
|
|
|
|
|
565
|
16
|
|
|
|
|
18
|
foreach my $rel_type (@rel_types) { |
|
566
|
16
|
50
|
33
|
|
|
32
|
if ( $rel_type->identifier || $term->identifier ) { |
|
567
|
0
|
0
|
|
|
|
0
|
return 1 if $rel_type->identifier eq $term->identifier; |
|
568
|
|
|
|
|
|
|
} else { |
|
569
|
16
|
100
|
|
|
|
23
|
return 1 if $rel_type->name eq $term->name; |
|
570
|
|
|
|
|
|
|
} |
|
571
|
|
|
|
|
|
|
} |
|
572
|
|
|
|
|
|
|
|
|
573
|
6
|
|
|
|
|
12
|
return 0; |
|
574
|
|
|
|
|
|
|
} |
|
575
|
|
|
|
|
|
|
|
|
576
|
|
|
|
|
|
|
=head2 _typed_traversal |
|
577
|
|
|
|
|
|
|
|
|
578
|
|
|
|
|
|
|
Title : _typed_traversal |
|
579
|
|
|
|
|
|
|
Usage : |
|
580
|
|
|
|
|
|
|
Function: |
|
581
|
|
|
|
|
|
|
Example : |
|
582
|
|
|
|
|
|
|
Returns : |
|
583
|
|
|
|
|
|
|
Args : |
|
584
|
|
|
|
|
|
|
|
|
585
|
|
|
|
|
|
|
=cut |
|
586
|
|
|
|
|
|
|
|
|
587
|
|
|
|
|
|
|
sub _typed_traversal { |
|
588
|
18
|
|
|
18
|
|
27
|
my ( $self, $rel_store, $level, $term_id, @rel_types ) = @_; |
|
589
|
18
|
50
|
|
|
|
31
|
return if !defined( $rel_store->{$term_id} ); |
|
590
|
18
|
|
|
|
|
18
|
my %parent_entry = %{ $rel_store->{$term_id} }; |
|
|
18
|
|
|
|
|
40
|
|
|
591
|
18
|
|
|
|
|
34
|
my @children = keys %parent_entry; |
|
592
|
|
|
|
|
|
|
|
|
593
|
18
|
|
|
|
|
18
|
my @ans; |
|
594
|
|
|
|
|
|
|
|
|
595
|
18
|
100
|
|
|
|
31
|
if ( @rel_types > 0 ) { |
|
596
|
10
|
|
|
|
|
10
|
@ans = (); |
|
597
|
|
|
|
|
|
|
|
|
598
|
10
|
|
|
|
|
11
|
foreach my $child_id (@children) { |
|
599
|
|
|
|
|
|
|
push @ans, $child_id |
|
600
|
16
|
100
|
|
|
|
28
|
if $self->_is_rel_type( $rel_store->{$term_id}->{$child_id}, @rel_types ); |
|
601
|
|
|
|
|
|
|
} |
|
602
|
|
|
|
|
|
|
} else { |
|
603
|
8
|
|
|
|
|
10
|
@ans = @children; |
|
604
|
|
|
|
|
|
|
} |
|
605
|
18
|
100
|
|
|
|
31
|
if ( $level < 1 ) { |
|
606
|
14
|
|
|
|
|
55
|
my @ans1 = (); |
|
607
|
|
|
|
|
|
|
|
|
608
|
14
|
|
|
|
|
15
|
foreach my $child_id (@ans) { |
|
609
|
|
|
|
|
|
|
push @ans1, $self->_typed_traversal( $rel_store, $level - 1, $child_id, @rel_types ) |
|
610
|
16
|
100
|
|
|
|
37
|
if defined $rel_store->{$child_id}; |
|
611
|
|
|
|
|
|
|
} |
|
612
|
14
|
|
|
|
|
47
|
push @ans, @ans1; |
|
613
|
|
|
|
|
|
|
} |
|
614
|
|
|
|
|
|
|
|
|
615
|
18
|
|
|
|
|
44
|
return @ans; |
|
616
|
|
|
|
|
|
|
} |
|
617
|
|
|
|
|
|
|
|
|
618
|
|
|
|
|
|
|
=head2 get_child_terms |
|
619
|
|
|
|
|
|
|
|
|
620
|
|
|
|
|
|
|
Title : get_child_terms |
|
621
|
|
|
|
|
|
|
Usage : get_child_terms(TermI term, TermI predicate_terms): TermI |
|
622
|
|
|
|
|
|
|
get_child_terms(TermI term, RelationshipType predicate_terms): TermI |
|
623
|
|
|
|
|
|
|
Function: Retrieves all child terms of a given term, that satisfy a |
|
624
|
|
|
|
|
|
|
relationship among those that are specified in the second |
|
625
|
|
|
|
|
|
|
argument or undef otherwise. get_child_terms is a special |
|
626
|
|
|
|
|
|
|
case of get_descendant_terms, limiting the search to the |
|
627
|
|
|
|
|
|
|
direct descendants. |
|
628
|
|
|
|
|
|
|
Example : |
|
629
|
|
|
|
|
|
|
Returns : Array of TermI objects. |
|
630
|
|
|
|
|
|
|
Args : First argument is the term of interest, second is the list of |
|
631
|
|
|
|
|
|
|
relationship type terms. |
|
632
|
|
|
|
|
|
|
|
|
633
|
|
|
|
|
|
|
=cut |
|
634
|
|
|
|
|
|
|
|
|
635
|
|
|
|
|
|
|
sub get_child_terms { |
|
636
|
3
|
|
|
3
|
1
|
6
|
my ( $self, $term, @relationship_types ) = @_; |
|
637
|
|
|
|
|
|
|
|
|
638
|
3
|
50
|
33
|
|
|
29
|
$self->throw("must provide TermI compliant object") |
|
639
|
|
|
|
|
|
|
unless defined($term) && $term->isa("Bio::Ontology::TermI"); |
|
640
|
|
|
|
|
|
|
|
|
641
|
3
|
|
|
|
|
7
|
return $self->_filter_unmarked( |
|
642
|
|
|
|
|
|
|
$self->get_term_by_identifier( |
|
643
|
|
|
|
|
|
|
$self->_typed_traversal( |
|
644
|
|
|
|
|
|
|
$self->_relationship_store, 1, $term->identifier, @relationship_types |
|
645
|
|
|
|
|
|
|
) |
|
646
|
|
|
|
|
|
|
) |
|
647
|
|
|
|
|
|
|
); |
|
648
|
|
|
|
|
|
|
} |
|
649
|
|
|
|
|
|
|
|
|
650
|
|
|
|
|
|
|
=head2 get_descendant_terms |
|
651
|
|
|
|
|
|
|
|
|
652
|
|
|
|
|
|
|
Title : get_descendant_terms |
|
653
|
|
|
|
|
|
|
Usage : get_descendant_terms(TermI term, TermI rel_types): TermI |
|
654
|
|
|
|
|
|
|
get_child_terms(TermI term, RelationshipType predicate_terms): TermI |
|
655
|
|
|
|
|
|
|
Function: Retrieves all descendant terms of a given term, that |
|
656
|
|
|
|
|
|
|
satisfy a relationship among those that are specified in |
|
657
|
|
|
|
|
|
|
the second argument or undef otherwise. Uses |
|
658
|
|
|
|
|
|
|
_typed_traversal to find all descendants. |
|
659
|
|
|
|
|
|
|
|
|
660
|
|
|
|
|
|
|
Example : |
|
661
|
|
|
|
|
|
|
Returns : Array of TermI objects. |
|
662
|
|
|
|
|
|
|
Args : First argument is the term of interest, second is the list of |
|
663
|
|
|
|
|
|
|
relationship type terms. |
|
664
|
|
|
|
|
|
|
|
|
665
|
|
|
|
|
|
|
=cut |
|
666
|
|
|
|
|
|
|
|
|
667
|
|
|
|
|
|
|
sub get_descendant_terms { |
|
668
|
3
|
|
|
3
|
1
|
6
|
my ( $self, $term, @relationship_types ) = @_; |
|
669
|
|
|
|
|
|
|
|
|
670
|
3
|
50
|
33
|
|
|
15
|
$self->throw("must provide TermI compliant object") |
|
671
|
|
|
|
|
|
|
unless defined($term) && $term->isa("Bio::Ontology::TermI"); |
|
672
|
|
|
|
|
|
|
|
|
673
|
3
|
|
|
|
|
8
|
return $self->_filter_unmarked( |
|
674
|
|
|
|
|
|
|
$self->_filter_repeated( |
|
675
|
|
|
|
|
|
|
$self->get_term_by_identifier( |
|
676
|
|
|
|
|
|
|
$self->_typed_traversal( |
|
677
|
|
|
|
|
|
|
$self->_relationship_store, 0, $term->identifier, @relationship_types |
|
678
|
|
|
|
|
|
|
) |
|
679
|
|
|
|
|
|
|
) |
|
680
|
|
|
|
|
|
|
) |
|
681
|
|
|
|
|
|
|
); |
|
682
|
|
|
|
|
|
|
} |
|
683
|
|
|
|
|
|
|
|
|
684
|
|
|
|
|
|
|
=head2 get_parent_terms |
|
685
|
|
|
|
|
|
|
|
|
686
|
|
|
|
|
|
|
Title : get_parent_terms |
|
687
|
|
|
|
|
|
|
Usage : get_parent_terms(TermI term, TermI predicate_terms): TermI |
|
688
|
|
|
|
|
|
|
get_child_terms(TermI term, RelationshipType predicate_terms): TermI |
|
689
|
|
|
|
|
|
|
Function: Retrieves all parent terms of a given term, that satisfy a |
|
690
|
|
|
|
|
|
|
relationship among those that are specified in the second |
|
691
|
|
|
|
|
|
|
argument or undef otherwise. get_parent_terms is a special |
|
692
|
|
|
|
|
|
|
case of get_ancestor_terms, limiting the search to the |
|
693
|
|
|
|
|
|
|
direct ancestors. |
|
694
|
|
|
|
|
|
|
|
|
695
|
|
|
|
|
|
|
Example : |
|
696
|
|
|
|
|
|
|
Returns : Array of TermI objects. |
|
697
|
|
|
|
|
|
|
Args : First argument is the term of interest, second is the list of relationship type terms. |
|
698
|
|
|
|
|
|
|
|
|
699
|
|
|
|
|
|
|
=cut |
|
700
|
|
|
|
|
|
|
|
|
701
|
|
|
|
|
|
|
sub get_parent_terms { |
|
702
|
1
|
|
|
1
|
1
|
3
|
my ( $self, $term, @relationship_types ) = @_; |
|
703
|
1
|
50
|
|
|
|
3
|
$self->throw("term must be a valid object, not undef") unless defined $term; |
|
704
|
|
|
|
|
|
|
|
|
705
|
1
|
|
|
|
|
3
|
return $self->_filter_unmarked( |
|
706
|
|
|
|
|
|
|
$self->get_term_by_identifier( |
|
707
|
|
|
|
|
|
|
$self->_typed_traversal( |
|
708
|
|
|
|
|
|
|
$self->_inverted_relationship_store, |
|
709
|
|
|
|
|
|
|
1, $term->identifier, @relationship_types |
|
710
|
|
|
|
|
|
|
) |
|
711
|
|
|
|
|
|
|
) |
|
712
|
|
|
|
|
|
|
); |
|
713
|
|
|
|
|
|
|
} |
|
714
|
|
|
|
|
|
|
|
|
715
|
|
|
|
|
|
|
=head2 get_ancestor_terms |
|
716
|
|
|
|
|
|
|
|
|
717
|
|
|
|
|
|
|
Title : get_ancestor_terms |
|
718
|
|
|
|
|
|
|
Usage : get_ancestor_terms(TermI term, TermI predicate_terms): TermI |
|
719
|
|
|
|
|
|
|
get_child_terms(TermI term, RelationshipType predicate_terms): TermI |
|
720
|
|
|
|
|
|
|
Function: Retrieves all ancestor terms of a given term, that satisfy |
|
721
|
|
|
|
|
|
|
a relationship among those that are specified in the second |
|
722
|
|
|
|
|
|
|
argument or undef otherwise. Uses _typed_traversal to find |
|
723
|
|
|
|
|
|
|
all ancestors. |
|
724
|
|
|
|
|
|
|
|
|
725
|
|
|
|
|
|
|
Example : |
|
726
|
|
|
|
|
|
|
Returns : Array of TermI objects. |
|
727
|
|
|
|
|
|
|
Args : First argument is the term of interest, second is the list |
|
728
|
|
|
|
|
|
|
of relationship type terms. |
|
729
|
|
|
|
|
|
|
|
|
730
|
|
|
|
|
|
|
=cut |
|
731
|
|
|
|
|
|
|
|
|
732
|
|
|
|
|
|
|
sub get_ancestor_terms { |
|
733
|
3
|
|
|
3
|
1
|
6
|
my ( $self, $term, @relationship_types ) = @_; |
|
734
|
3
|
50
|
|
|
|
6
|
$self->throw("term must be a valid object, not undef") unless defined $term; |
|
735
|
|
|
|
|
|
|
|
|
736
|
3
|
|
|
|
|
7
|
return $self->_filter_unmarked( |
|
737
|
|
|
|
|
|
|
$self->_filter_repeated( |
|
738
|
|
|
|
|
|
|
$self->get_term_by_identifier( |
|
739
|
|
|
|
|
|
|
$self->_typed_traversal( |
|
740
|
|
|
|
|
|
|
$self->_inverted_relationship_store, 0, |
|
741
|
|
|
|
|
|
|
$term->identifier, @relationship_types |
|
742
|
|
|
|
|
|
|
) |
|
743
|
|
|
|
|
|
|
) |
|
744
|
|
|
|
|
|
|
) |
|
745
|
|
|
|
|
|
|
); |
|
746
|
|
|
|
|
|
|
} |
|
747
|
|
|
|
|
|
|
|
|
748
|
|
|
|
|
|
|
=head2 get_leaf_terms |
|
749
|
|
|
|
|
|
|
|
|
750
|
|
|
|
|
|
|
Title : get_leaf_terms |
|
751
|
|
|
|
|
|
|
Usage : get_leaf_terms(): TermI |
|
752
|
|
|
|
|
|
|
Function: Retrieves all leaf terms from the ontology. Leaf term is a term w/o descendants. |
|
753
|
|
|
|
|
|
|
Example : @leaf_terms = $obj->get_leaf_terms() |
|
754
|
|
|
|
|
|
|
Returns : Array of TermI objects. |
|
755
|
|
|
|
|
|
|
Args : |
|
756
|
|
|
|
|
|
|
|
|
757
|
|
|
|
|
|
|
=cut |
|
758
|
|
|
|
|
|
|
|
|
759
|
|
|
|
|
|
|
sub get_leaf_terms { |
|
760
|
1
|
|
|
1
|
1
|
2
|
my ($self) = @_; |
|
761
|
1
|
|
|
|
|
2
|
my @leaf_terms; |
|
762
|
|
|
|
|
|
|
|
|
763
|
1
|
|
|
|
|
2
|
foreach my $term ( values %{ $self->_term_store } ) { |
|
|
1
|
|
|
|
|
2
|
|
|
764
|
|
|
|
|
|
|
push @leaf_terms, $term |
|
765
|
|
|
|
|
|
|
if !defined $self->_relationship_store->{ $term->identifier } |
|
766
|
4
|
100
|
66
|
|
|
6
|
&& defined $self->_instantiated_terms_store->{ $term->identifier }; |
|
767
|
|
|
|
|
|
|
} |
|
768
|
|
|
|
|
|
|
|
|
769
|
1
|
|
|
|
|
2
|
return @leaf_terms; |
|
770
|
|
|
|
|
|
|
} |
|
771
|
|
|
|
|
|
|
|
|
772
|
|
|
|
|
|
|
=head2 get_root_terms |
|
773
|
|
|
|
|
|
|
|
|
774
|
|
|
|
|
|
|
Title : get_root_terms |
|
775
|
|
|
|
|
|
|
Usage : get_root_terms(): TermI |
|
776
|
|
|
|
|
|
|
Function: Retrieves all root terms from the ontology. Root term is a term w/o descendants. |
|
777
|
|
|
|
|
|
|
Example : @root_terms = $obj->get_root_terms() |
|
778
|
|
|
|
|
|
|
Returns : Array of TermI objects. |
|
779
|
|
|
|
|
|
|
Args : |
|
780
|
|
|
|
|
|
|
|
|
781
|
|
|
|
|
|
|
=cut |
|
782
|
|
|
|
|
|
|
|
|
783
|
|
|
|
|
|
|
sub get_root_terms { |
|
784
|
1
|
|
|
1
|
1
|
2
|
my ($self) = @_; |
|
785
|
1
|
|
|
|
|
2
|
my @root_terms; |
|
786
|
|
|
|
|
|
|
|
|
787
|
1
|
|
|
|
|
2
|
foreach my $term ( values %{ $self->_term_store } ) { |
|
|
1
|
|
|
|
|
2
|
|
|
788
|
|
|
|
|
|
|
push @root_terms, $term |
|
789
|
|
|
|
|
|
|
if !defined $self->_inverted_relationship_store->{ $term->identifier } |
|
790
|
4
|
100
|
66
|
|
|
7
|
&& defined $self->_instantiated_terms_store->{ $term->identifier }; |
|
791
|
|
|
|
|
|
|
} |
|
792
|
|
|
|
|
|
|
|
|
793
|
1
|
|
|
|
|
3
|
return @root_terms; |
|
794
|
|
|
|
|
|
|
} |
|
795
|
|
|
|
|
|
|
|
|
796
|
|
|
|
|
|
|
=head2 _filter_repeated |
|
797
|
|
|
|
|
|
|
|
|
798
|
|
|
|
|
|
|
Title : _filter_repeated |
|
799
|
|
|
|
|
|
|
Usage : @lst = $self->_filter_repeated(@old_lst); |
|
800
|
|
|
|
|
|
|
Function: Removes repeated terms |
|
801
|
|
|
|
|
|
|
Example : |
|
802
|
|
|
|
|
|
|
Returns : List of unique TermI objects |
|
803
|
|
|
|
|
|
|
Args : List of TermI objects |
|
804
|
|
|
|
|
|
|
|
|
805
|
|
|
|
|
|
|
=cut |
|
806
|
|
|
|
|
|
|
|
|
807
|
|
|
|
|
|
|
sub _filter_repeated { |
|
808
|
6
|
|
|
6
|
|
7
|
my ( $self, @args ) = @_; |
|
809
|
6
|
|
|
|
|
8
|
my %h; |
|
810
|
|
|
|
|
|
|
|
|
811
|
6
|
|
|
|
|
7
|
foreach my $element (@args) { |
|
812
|
16
|
100
|
|
|
|
24
|
$h{ $element->identifier } = $element if !defined $h{ $element->identifier }; |
|
813
|
|
|
|
|
|
|
} |
|
814
|
|
|
|
|
|
|
|
|
815
|
6
|
|
|
|
|
15
|
return values %h; |
|
816
|
|
|
|
|
|
|
} |
|
817
|
|
|
|
|
|
|
|
|
818
|
|
|
|
|
|
|
=head2 get_all_terms |
|
819
|
|
|
|
|
|
|
|
|
820
|
|
|
|
|
|
|
Title : get_all_terms |
|
821
|
|
|
|
|
|
|
Usage : get_all_terms(): TermI |
|
822
|
|
|
|
|
|
|
Function: Retrieves all terms currently stored in the ontology. |
|
823
|
|
|
|
|
|
|
Example : @all_terms = $obj->get_all_terms() |
|
824
|
|
|
|
|
|
|
Returns : Array of TermI objects. |
|
825
|
|
|
|
|
|
|
Args : |
|
826
|
|
|
|
|
|
|
|
|
827
|
|
|
|
|
|
|
=cut |
|
828
|
|
|
|
|
|
|
|
|
829
|
|
|
|
|
|
|
sub get_all_terms { |
|
830
|
0
|
|
|
0
|
1
|
0
|
my ($self) = @_; |
|
831
|
|
|
|
|
|
|
|
|
832
|
0
|
|
|
|
|
0
|
return $self->_filter_unmarked( values %{ $self->_term_store } ); |
|
|
0
|
|
|
|
|
0
|
|
|
833
|
|
|
|
|
|
|
} |
|
834
|
|
|
|
|
|
|
|
|
835
|
|
|
|
|
|
|
=head2 find_terms |
|
836
|
|
|
|
|
|
|
|
|
837
|
|
|
|
|
|
|
Title : find_terms |
|
838
|
|
|
|
|
|
|
Usage : ($term) = $oe->find_terms(-identifier => "SO:0000263"); |
|
839
|
|
|
|
|
|
|
Function: Find term instances matching queries for their attributes. |
|
840
|
|
|
|
|
|
|
|
|
841
|
|
|
|
|
|
|
This implementation can efficiently resolve queries by |
|
842
|
|
|
|
|
|
|
identifier. |
|
843
|
|
|
|
|
|
|
|
|
844
|
|
|
|
|
|
|
Example : |
|
845
|
|
|
|
|
|
|
Returns : an array of zero or more Bio::Ontology::TermI objects |
|
846
|
|
|
|
|
|
|
Args : Named parameters. The following parameters should be recognized |
|
847
|
|
|
|
|
|
|
by any implementations: |
|
848
|
|
|
|
|
|
|
|
|
849
|
|
|
|
|
|
|
-identifier query by the given identifier |
|
850
|
|
|
|
|
|
|
-name query by the given name |
|
851
|
|
|
|
|
|
|
|
|
852
|
|
|
|
|
|
|
=cut |
|
853
|
|
|
|
|
|
|
|
|
854
|
|
|
|
|
|
|
sub find_terms { |
|
855
|
0
|
|
|
0
|
1
|
0
|
my ( $self, @args ) = @_; |
|
856
|
0
|
|
|
|
|
0
|
my @terms; |
|
857
|
|
|
|
|
|
|
|
|
858
|
0
|
|
|
|
|
0
|
my ( $id, $name ) = $self->_rearrange( [qw(IDENTIFIER NAME)], @args ); |
|
859
|
|
|
|
|
|
|
|
|
860
|
0
|
0
|
|
|
|
0
|
if ( defined($id) ) { |
|
861
|
0
|
|
|
|
|
0
|
@terms = $self->get_term_by_identifier($id); |
|
862
|
|
|
|
|
|
|
} else { |
|
863
|
0
|
|
|
|
|
0
|
@terms = $self->get_all_terms(); |
|
864
|
|
|
|
|
|
|
} |
|
865
|
0
|
0
|
|
|
|
0
|
if ( defined($name) ) { |
|
866
|
0
|
|
|
|
|
0
|
@terms = grep { $_->name() eq $name; } @terms; |
|
|
0
|
|
|
|
|
0
|
|
|
867
|
|
|
|
|
|
|
} |
|
868
|
0
|
|
|
|
|
0
|
return @terms; |
|
869
|
|
|
|
|
|
|
} |
|
870
|
|
|
|
|
|
|
|
|
871
|
|
|
|
|
|
|
=head2 relationship_factory |
|
872
|
|
|
|
|
|
|
|
|
873
|
|
|
|
|
|
|
Title : relationship_factory |
|
874
|
|
|
|
|
|
|
Usage : $fact = $obj->relationship_factory() |
|
875
|
|
|
|
|
|
|
Function: Get/set the object factory to be used when relationship |
|
876
|
|
|
|
|
|
|
objects are created by the implementation on-the-fly. |
|
877
|
|
|
|
|
|
|
|
|
878
|
|
|
|
|
|
|
Example : |
|
879
|
|
|
|
|
|
|
Returns : value of relationship_factory (a Bio::Factory::ObjectFactoryI |
|
880
|
|
|
|
|
|
|
compliant object) |
|
881
|
|
|
|
|
|
|
Args : on set, a Bio::Factory::ObjectFactoryI compliant object |
|
882
|
|
|
|
|
|
|
|
|
883
|
|
|
|
|
|
|
=cut |
|
884
|
|
|
|
|
|
|
|
|
885
|
|
|
|
|
|
|
sub relationship_factory { |
|
886
|
1
|
|
|
1
|
1
|
2
|
my $self = shift; |
|
887
|
|
|
|
|
|
|
|
|
888
|
1
|
50
|
|
|
|
3
|
return $self->{'relationship_factory'} = shift if @_; |
|
889
|
0
|
|
|
|
|
0
|
return $self->{'relationship_factory'}; |
|
890
|
|
|
|
|
|
|
} |
|
891
|
|
|
|
|
|
|
|
|
892
|
|
|
|
|
|
|
=head2 term_factory |
|
893
|
|
|
|
|
|
|
|
|
894
|
|
|
|
|
|
|
Title : term_factory |
|
895
|
|
|
|
|
|
|
Usage : $fact = $obj->term_factory() |
|
896
|
|
|
|
|
|
|
Function: Get/set the object factory to be used when term objects are |
|
897
|
|
|
|
|
|
|
created by the implementation on-the-fly. |
|
898
|
|
|
|
|
|
|
|
|
899
|
|
|
|
|
|
|
Note that this ontology engine implementation does not |
|
900
|
|
|
|
|
|
|
create term objects on the fly, and therefore setting this |
|
901
|
|
|
|
|
|
|
attribute is meaningless. |
|
902
|
|
|
|
|
|
|
|
|
903
|
|
|
|
|
|
|
Example : |
|
904
|
|
|
|
|
|
|
Returns : value of term_factory (a Bio::Factory::ObjectFactoryI |
|
905
|
|
|
|
|
|
|
compliant object) |
|
906
|
|
|
|
|
|
|
Args : on set, a Bio::Factory::ObjectFactoryI compliant object |
|
907
|
|
|
|
|
|
|
|
|
908
|
|
|
|
|
|
|
=cut |
|
909
|
|
|
|
|
|
|
|
|
910
|
|
|
|
|
|
|
sub term_factory { |
|
911
|
0
|
|
|
0
|
1
|
0
|
my $self = shift; |
|
912
|
|
|
|
|
|
|
|
|
913
|
0
|
0
|
|
|
|
0
|
if (@_) { |
|
914
|
0
|
|
|
|
|
0
|
$self->warn( |
|
915
|
|
|
|
|
|
|
"setting term factory, but " . ref($self) . " does not create terms on-the-fly" ); |
|
916
|
0
|
|
|
|
|
0
|
return $self->{'term_factory'} = shift; |
|
917
|
|
|
|
|
|
|
} |
|
918
|
0
|
|
|
|
|
0
|
return $self->{'term_factory'}; |
|
919
|
|
|
|
|
|
|
} |
|
920
|
|
|
|
|
|
|
|
|
921
|
|
|
|
|
|
|
=head2 _filter_unmarked |
|
922
|
|
|
|
|
|
|
|
|
923
|
|
|
|
|
|
|
Title : _filter_unmarked |
|
924
|
|
|
|
|
|
|
Usage : _filter_unmarked(TermI terms): TermI |
|
925
|
|
|
|
|
|
|
Function: Removes the uninstantiated terms from the list of terms |
|
926
|
|
|
|
|
|
|
Example : |
|
927
|
|
|
|
|
|
|
Returns : array of fully instantiated TermI objects |
|
928
|
|
|
|
|
|
|
Args : array of TermI objects |
|
929
|
|
|
|
|
|
|
|
|
930
|
|
|
|
|
|
|
=cut |
|
931
|
|
|
|
|
|
|
|
|
932
|
|
|
|
|
|
|
sub _filter_unmarked { |
|
933
|
10
|
|
|
10
|
|
13
|
my ( $self, @terms ) = @_; |
|
934
|
10
|
|
|
|
|
14
|
my @filtered_terms = (); |
|
935
|
|
|
|
|
|
|
|
|
936
|
10
|
100
|
|
|
|
17
|
if ( scalar(@terms) >= 1 ) { |
|
937
|
7
|
|
|
|
|
8
|
foreach my $term (@terms) { |
|
938
|
|
|
|
|
|
|
push @filtered_terms, $term |
|
939
|
17
|
50
|
|
|
|
27
|
if defined $self->_instantiated_terms_store->{ $term->identifier }; |
|
940
|
|
|
|
|
|
|
} |
|
941
|
|
|
|
|
|
|
} |
|
942
|
|
|
|
|
|
|
|
|
943
|
10
|
|
|
|
|
80
|
return @filtered_terms; |
|
944
|
|
|
|
|
|
|
} |
|
945
|
|
|
|
|
|
|
|
|
946
|
|
|
|
|
|
|
=head2 remove_term_by_id |
|
947
|
|
|
|
|
|
|
|
|
948
|
|
|
|
|
|
|
Title : remove_term_by_id |
|
949
|
|
|
|
|
|
|
Usage : remove_term_by_id(String id): TermI |
|
950
|
|
|
|
|
|
|
Function: Removes TermI object from the ontology engine using the |
|
951
|
|
|
|
|
|
|
string id as an identifier. Current implementation does not |
|
952
|
|
|
|
|
|
|
enforce consistency of the relationships using that term. |
|
953
|
|
|
|
|
|
|
Example : $term = $soe->remove_term_by_id($id); |
|
954
|
|
|
|
|
|
|
Returns : Object of class TermI or undef if not found. |
|
955
|
|
|
|
|
|
|
Args : The string identifier of a term. |
|
956
|
|
|
|
|
|
|
|
|
957
|
|
|
|
|
|
|
=cut |
|
958
|
|
|
|
|
|
|
|
|
959
|
|
|
|
|
|
|
sub remove_term_by_id { |
|
960
|
0
|
|
|
0
|
1
|
0
|
my ( $self, $id ) = @_; |
|
961
|
|
|
|
|
|
|
|
|
962
|
0
|
0
|
|
|
|
0
|
if ( $self->get_term_by_identifier($id) ) { |
|
963
|
0
|
|
|
|
|
0
|
my $term = $self->{_term_store}->{$id}; |
|
964
|
0
|
|
|
|
|
0
|
delete $self->{_term_store}->{$id}; |
|
965
|
0
|
|
|
|
|
0
|
return $term; |
|
966
|
|
|
|
|
|
|
} else { |
|
967
|
0
|
|
|
|
|
0
|
$self->warn("Term with id '$id' is not in the term store"); |
|
968
|
0
|
|
|
|
|
0
|
return; |
|
969
|
|
|
|
|
|
|
} |
|
970
|
|
|
|
|
|
|
} |
|
971
|
|
|
|
|
|
|
|
|
972
|
|
|
|
|
|
|
=head2 to_string |
|
973
|
|
|
|
|
|
|
|
|
974
|
|
|
|
|
|
|
Title : to_string |
|
975
|
|
|
|
|
|
|
Usage : print $sv->to_string(); |
|
976
|
|
|
|
|
|
|
Function: Currently returns formatted string containing the number of |
|
977
|
|
|
|
|
|
|
terms and number of relationships from the ontology engine. |
|
978
|
|
|
|
|
|
|
Example : print $sv->to_string(); |
|
979
|
|
|
|
|
|
|
Returns : |
|
980
|
|
|
|
|
|
|
Args : |
|
981
|
|
|
|
|
|
|
|
|
982
|
|
|
|
|
|
|
=cut |
|
983
|
|
|
|
|
|
|
|
|
984
|
|
|
|
|
|
|
sub to_string { |
|
985
|
0
|
|
|
0
|
1
|
0
|
my ($self) = @_; |
|
986
|
0
|
|
|
|
|
0
|
my $s = ""; |
|
987
|
|
|
|
|
|
|
|
|
988
|
0
|
|
|
|
|
0
|
$s .= "-- # Terms:\n"; |
|
989
|
0
|
|
|
|
|
0
|
$s .= scalar( $self->get_all_terms ) . "\n"; |
|
990
|
0
|
|
|
|
|
0
|
$s .= "-- # Relationships:\n"; |
|
991
|
0
|
|
|
|
|
0
|
$s .= $self->_get_number_rels . "\n"; |
|
992
|
|
|
|
|
|
|
|
|
993
|
0
|
|
|
|
|
0
|
return $s; |
|
994
|
|
|
|
|
|
|
} |
|
995
|
|
|
|
|
|
|
|
|
996
|
|
|
|
|
|
|
=head2 _unique_termid |
|
997
|
|
|
|
|
|
|
|
|
998
|
|
|
|
|
|
|
Title : _unique_termid |
|
999
|
|
|
|
|
|
|
Usage : |
|
1000
|
|
|
|
|
|
|
Function: Returns a string that can be used as ID using fail-over |
|
1001
|
|
|
|
|
|
|
approaches. |
|
1002
|
|
|
|
|
|
|
|
|
1003
|
|
|
|
|
|
|
If the identifier attribute is not set, it uses the |
|
1004
|
|
|
|
|
|
|
combination of name and ontology name, provided both are |
|
1005
|
|
|
|
|
|
|
set. If they are not, it returns the name alone. |
|
1006
|
|
|
|
|
|
|
|
|
1007
|
|
|
|
|
|
|
Note that this is a private method. Call from inheriting |
|
1008
|
|
|
|
|
|
|
classes but not from outside. |
|
1009
|
|
|
|
|
|
|
|
|
1010
|
|
|
|
|
|
|
Example : |
|
1011
|
|
|
|
|
|
|
Returns : a string |
|
1012
|
|
|
|
|
|
|
Args : a Bio::Ontology::TermI compliant object |
|
1013
|
|
|
|
|
|
|
|
|
1014
|
|
|
|
|
|
|
=cut |
|
1015
|
|
|
|
|
|
|
|
|
1016
|
|
|
|
|
|
|
sub _unique_termid { |
|
1017
|
4
|
|
|
4
|
|
5
|
my $self = shift; |
|
1018
|
4
|
|
|
|
|
4
|
my $term = shift; |
|
1019
|
|
|
|
|
|
|
|
|
1020
|
4
|
50
|
|
|
|
8
|
return $term->identifier() if $term->identifier(); |
|
1021
|
4
|
50
|
|
|
|
8
|
my $id = $term->ontology->name() if $term->ontology(); |
|
1022
|
4
|
50
|
|
|
|
9
|
if ($id) { |
|
1023
|
4
|
|
|
|
|
6
|
$id .= '|'; |
|
1024
|
|
|
|
|
|
|
} else { |
|
1025
|
0
|
|
|
|
|
0
|
$id = ''; |
|
1026
|
|
|
|
|
|
|
} |
|
1027
|
4
|
|
|
|
|
8
|
$id .= $term->name(); |
|
1028
|
|
|
|
|
|
|
} |
|
1029
|
|
|
|
|
|
|
|
|
1030
|
|
|
|
|
|
|
################################################################# |
|
1031
|
|
|
|
|
|
|
# aliases |
|
1032
|
|
|
|
|
|
|
################################################################# |
|
1033
|
|
|
|
|
|
|
|
|
1034
|
|
|
|
|
|
|
*get_relationship_types = \&get_predicate_terms; |
|
1035
|
|
|
|
|
|
|
|
|
1036
|
|
|
|
|
|
|
1; |