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# |
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# BioPerl module for OntologyEngineI |
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# |
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# Please direct questions and support issues to |
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# |
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# Cared for by Peter Dimitrov |
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# |
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# (c) Peter Dimitrov |
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# (c) GNF, Genomics Institute of the Novartis Research Foundation, 2002. |
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# |
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# You may distribute this module under the same terms as perl itself. |
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# Refer to the Perl Artistic License (see the license accompanying this |
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# software package, or see http://www.perl.com/language/misc/Artistic.html) |
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# for the terms under which you may use, modify, and redistribute this module. |
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# |
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# THIS PACKAGE IS PROVIDED "AS IS" AND WITHOUT ANY EXPRESS OR IMPLIED |
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# WARRANTIES, INCLUDING, WITHOUT LIMITATION, THE IMPLIED WARRANTIES OF |
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# MERCHANTIBILITY AND FITNESS FOR A PARTICULAR PURPOSE. |
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# |
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# You may distribute this module under the same terms as perl itself |
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# POD documentation - main docs before the code |
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=head1 NAME |
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Bio::Ontology::OntologyEngineI - Interface a minimal Ontology implementation should satisfy |
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=head1 SYNOPSIS |
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# see documentation of methods |
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=head1 DESCRIPTION |
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This describes the minimal interface an ontology query engine should |
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provide. It intentionally does not make explicit references to the |
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ontology being a DAG, nor does it mandate that the ontology be a |
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vocabulary. Rather, it tries to generically express what should be |
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accessible (queriable) about an ontology. |
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The idea is to allow for different implementations for different |
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purposes, which may then differ as to which operations are efficient |
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and which are not, and how much richer the functionality is on top of |
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this minimalistic set of methods. Check modules in the Bio::Ontology |
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namespace to find out which implementations exist. At the time of |
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writing, there is a SimpleOntologyEngine (which does not use |
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Graph.pm), and a Graph.pm-based implementation in SimpleGOEngine. |
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Ontology parsers in Bio::OntologyIO are required to return an |
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implementation of this interface. |
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=head1 FEEDBACK |
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=head2 Mailing Lists |
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User feedback is an integral part of the evolution of this and other |
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Bioperl modules. Send your comments and suggestions preferably to |
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the Bioperl mailing list. Your participation is much appreciated. |
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bioperl-l@bioperl.org - General discussion |
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http://bioperl.org/wiki/Mailing_lists - About the mailing lists |
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=head2 Support |
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Please direct usage questions or support issues to the mailing list: |
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I |
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rather than to the module maintainer directly. Many experienced and |
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reponsive experts will be able look at the problem and quickly |
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address it. Please include a thorough description of the problem |
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with code and data examples if at all possible. |
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=head2 Reporting Bugs |
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Report bugs to the Bioperl bug tracking system to help us keep track |
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of the bugs and their resolution. Bug reports can be submitted via |
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the web: |
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https://github.com/bioperl/bioperl-live/issues |
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=head1 AUTHOR - Peter Dimitrov |
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Email dimitrov@gnf.org |
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=head1 APPENDIX |
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The rest of the documentation details each of the object methods. |
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Internal methods are usually preceded with a _ |
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=cut |
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# Let the code begin... |
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package Bio::Ontology::OntologyEngineI; |
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use strict; |
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use Carp; |
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use base qw(Bio::Root::RootI); |
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=head2 add_term |
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Title : add_term |
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Usage : add_term(TermI term): TermI |
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Function: Adds TermI object to the ontology engine term store |
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Example : $oe->add_term($term) |
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Returns : its argument. |
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Args : object of class TermI. |
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=cut |
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sub add_term{ |
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} |
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=head2 add_relationship |
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Title : add_relationship |
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Usage : add_relationship(RelationshipI relationship): RelationshipI |
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Function: Adds a relationship object to the ontology engine. |
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Example : |
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Returns : Its argument. |
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Args : A RelationshipI object. |
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=cut |
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sub add_relationship{ |
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} |
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=head2 add_relationship_type |
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Title : add_relationship_type |
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Usage : add_relationship_type(scalar,OntologyI ontology) |
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Function: Adds a relationshiptype object to the ontology engine. |
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Example : |
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Returns : 1 on success, undef on failure |
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Args : The name(scalar) of the relationshiptype, and the OntologyI |
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it is to be added to. |
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=cut |
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sub add_relationship_type{ |
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} |
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=head2 get_relationship_type |
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Title : get_relationship_type |
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Usage : get_relationship_type(scalar): RelationshipTypeI |
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Function: Get a relationshiptype object from the ontology engine. |
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Example : |
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Returns : A RelationshipTypeI object. |
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Args : The name (scalar) of the RelationshipTypeI object desired. |
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=cut |
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sub get_relationship_type{ |
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shift->throw_not_implemented(); |
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} |
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=head2 get_relationships |
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Title : get_relationships |
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Usage : get_relationships(TermI term): RelationshipI |
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Function: Retrieves all relationship objects from this ontology engine, |
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or all relationships of a term if a term is supplied. |
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Example : |
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Returns : Array of Bio::Ontology::RelationshipI objects |
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Args : None, or a Bio::Ontology::TermI compliant object for which |
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to retrieve the relationships. |
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=cut |
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sub get_relationships{ |
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} |
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=head2 get_predicate_terms |
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Title : get_predicate_terms |
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Usage : get_predicate_terms(): TermI |
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Function: |
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Example : |
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Returns : |
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Args : |
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=cut |
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sub get_predicate_terms{ |
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} |
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=head2 get_child_terms |
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Title : get_child_terms |
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Usage : get_child_terms(TermI term, TermI predicate_terms): TermI |
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Function: Retrieves all child terms of a given term, that satisfy a |
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relationship among those that are specified in the second |
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argument or undef otherwise. get_child_terms is a special |
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case of get_descendant_terms, limiting the search to the |
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direct descendants. |
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Example : |
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Returns : Array of TermI objects. |
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Args : First argument is the term of interest, second is the list |
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of relationship type terms. |
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=cut |
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sub get_child_terms{ |
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} |
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=head2 get_descendant_terms |
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Title : get_descendant_terms |
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Usage : get_descendant_terms(TermI term, TermI rel_types): TermI |
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Function: Retrieves all descendant terms of a given term, that |
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satisfy a relationship among those that are specified in |
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the second argument or undef otherwise. |
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Example : |
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Returns : Array of TermI objects. |
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Args : First argument is the term of interest, second is the list |
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of relationship type terms. |
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sub get_descendant_terms{ |
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shift->throw_not_implemented(); |
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} |
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=head2 get_parent_terms |
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Title : get_parent_terms |
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Usage : get_parent_terms(TermI term, TermI predicate_terms): TermI |
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Function: Retrieves all parent terms of a given term, that satisfy a |
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relationship among those that are specified in the second |
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argument or undef otherwise. get_parent_terms is a special |
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case of get_ancestor_terms, limiting the search to the |
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direct ancestors. |
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Example : |
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Returns : Array of TermI objects. |
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Args : First argument is the term of interest, second is the list |
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of relationship type terms. |
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=cut |
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sub get_parent_terms{ |
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shift->throw_not_implemented(); |
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} |
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255
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=head2 get_ancestor_terms |
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257
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Title : get_ancestor_terms |
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Usage : get_ancestor_terms(TermI term, TermI predicate_terms): TermI |
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Function: Retrieves all ancestor terms of a given term, that satisfy |
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a relationship among those that are specified in the second |
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argument or undef otherwise. |
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263
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Example : |
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Returns : Array of TermI objects. |
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Args : First argument is the term of interest, second is the list |
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of relationship type terms. |
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268
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=cut |
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269
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270
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sub get_ancestor_terms{ |
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0
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shift->throw_not_implemented(); |
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} |
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273
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274
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=head2 get_leaf_terms |
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275
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276
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Title : get_leaf_terms |
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277
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Usage : get_leaf_terms(): TermI |
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278
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Function: Retrieves all leaf terms from the ontology. Leaf term is a |
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279
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term w/o descendants. |
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280
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281
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Example : @leaf_terms = $obj->get_leaf_terms() |
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282
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Returns : Array of TermI objects. |
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283
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Args : |
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284
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285
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=cut |
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286
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287
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sub get_leaf_terms{ |
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288
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0
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0
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1
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shift->throw_not_implemented(); |
|
289
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} |
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290
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291
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=head2 get_root_terms |
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292
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293
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Title : get_root_terms |
|
294
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Usage : get_root_terms(): TermI |
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295
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Function: Retrieves all root terms from the ontology. Root term is a |
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296
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term w/o ancestors. |
|
297
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298
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Example : @root_terms = $obj->get_root_terms() |
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299
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Returns : Array of TermI objects. |
|
300
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Args : |
|
301
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302
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=cut |
|
303
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304
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|
sub get_root_terms{ |
|
305
|
0
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0
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1
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|
shift->throw_not_implemented(); |
|
306
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} |
|
307
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308
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|
=head1 Factory for relationships and terms |
|
309
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310
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=cut |
|
311
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312
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|
=head2 relationship_factory |
|
313
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314
|
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|
Title : relationship_factory |
|
315
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|
Usage : $fact = $obj->relationship_factory() |
|
316
|
|
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|
Function: Get (and set, if the implementation supports it) the object |
|
317
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|
factory to be used when relationship objects are created by |
|
318
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|
the implementation on-the-fly. |
|
319
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|
320
|
|
|
|
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|
|
Example : |
|
321
|
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|
|
Returns : value of relationship_factory (a Bio::Factory::ObjectFactory |
|
322
|
|
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|
|
|
compliant object) |
|
323
|
|
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|
|
Args : |
|
324
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325
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|
=cut |
|
326
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|
327
|
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|
sub relationship_factory{ |
|
328
|
0
|
|
|
0
|
1
|
|
return shift->throw_not_implemented(); |
|
329
|
|
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|
|
} |
|
330
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|
331
|
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|
=head2 term_factory |
|
332
|
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|
333
|
|
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|
|
|
|
Title : term_factory |
|
334
|
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|
|
Usage : $fact = $obj->term_factory() |
|
335
|
|
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|
|
Function: Get (and set, if the implementation supports it) the object |
|
336
|
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|
|
factory to be used when term objects are created by |
|
337
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|
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|
|
the implementation on-the-fly. |
|
338
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|
339
|
|
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|
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|
|
Example : |
|
340
|
|
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|
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|
|
Returns : value of term_factory (a Bio::Factory::ObjectFactory |
|
341
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|
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|
|
compliant object) |
|
342
|
|
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|
|
Args : |
|
343
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|
344
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|
=cut |
|
345
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|
346
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|
|
sub term_factory{ |
|
347
|
0
|
|
|
0
|
1
|
|
return shift->throw_not_implemented(); |
|
348
|
|
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|
|
} |
|
349
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|
350
|
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|
|
=head1 Decorator Methods |
|
351
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|
352
|
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|
|
These methods come with a default implementation that uses the |
|
353
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|
|
abstract methods defined for this interface. This may not be very |
|
354
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|
|
efficient, and hence implementors are encouraged to override these |
|
355
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|
|
methods if they can provide more efficient implementations. |
|
356
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|
357
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|
|
=cut |
|
358
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|
359
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|
|
=head2 get_all_terms |
|
360
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|
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|
361
|
|
|
|
|
|
|
Title : get_all_terms |
|
362
|
|
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|
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|
|
Usage : get_all_terms: TermI |
|
363
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|
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|
|
|
Function: Retrieves all terms from the ontology. |
|
364
|
|
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|
365
|
|
|
|
|
|
|
This is more a decorator method. We provide a default |
|
366
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|
|
implementation here that loops over all root terms and gets |
|
367
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|
|
all descendants for each root term. The overall union of |
|
368
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|
|
terms is then made unique by name and ontology. |
|
369
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|
370
|
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|
|
We do not mandate an order here in which the terms are |
|
371
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|
|
returned. In fact, the default implementation will return |
|
372
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|
|
them in unpredictable order. |
|
373
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|
374
|
|
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|
|
Engine implementations that can provide a more efficient |
|
375
|
|
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|
|
method for obtaining all terms should definitely override |
|
376
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|
|
this. |
|
377
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|
378
|
|
|
|
|
|
|
Example : @terms = $obj->get_all_terms() |
|
379
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|
|
Returns : Array of TermI objects. |
|
380
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|
|
Args : |
|
381
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|
382
|
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|
|
=cut |
|
383
|
|
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|
|
|
|
|
|
384
|
|
|
|
|
|
|
sub get_all_terms{ |
|
385
|
0
|
|
|
0
|
1
|
|
my $self = shift; |
|
386
|
|
|
|
|
|
|
# get all root nodes |
|
387
|
0
|
|
|
|
|
|
my @roots = $self->get_root_terms(); |
|
388
|
|
|
|
|
|
|
# accumulate all descendants for each root term |
|
389
|
0
|
|
|
|
|
|
my @terms = map { $self->get_descendant_terms($_); } @roots; |
|
|
0
|
|
|
|
|
|
|
|
390
|
|
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|
|
|
|
# add on the root terms themselves |
|
391
|
0
|
|
|
|
|
|
push(@terms, @roots); |
|
392
|
|
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|
|
# make unique by name and ontology |
|
393
|
0
|
|
|
|
|
|
my %name_map = map { ($_->name."@".$_->ontology->name, $_); } @terms; |
|
|
0
|
|
|
|
|
|
|
|
394
|
|
|
|
|
|
|
# done |
|
395
|
0
|
|
|
|
|
|
return values %name_map; |
|
396
|
|
|
|
|
|
|
} |
|
397
|
|
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|
398
|
|
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|
|
=head2 find_terms |
|
399
|
|
|
|
|
|
|
|
|
400
|
|
|
|
|
|
|
Title : find_terms |
|
401
|
|
|
|
|
|
|
Usage : ($term) = $oe->find_terms(-identifier => "SO:0000263"); |
|
402
|
|
|
|
|
|
|
Function: Find term instances matching queries for their attributes. |
|
403
|
|
|
|
|
|
|
|
|
404
|
|
|
|
|
|
|
An implementation may not support querying for arbitrary |
|
405
|
|
|
|
|
|
|
attributes, but can generally be expected to accept |
|
406
|
|
|
|
|
|
|
-identifier and -name as queries. If both are provided, |
|
407
|
|
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|
|
|
|
they are implicitly intersected. |
|
408
|
|
|
|
|
|
|
|
|
409
|
|
|
|
|
|
|
Example : |
|
410
|
|
|
|
|
|
|
Returns : an array of zero or more Bio::Ontology::TermI objects |
|
411
|
|
|
|
|
|
|
Args : Named parameters. The following parameters should be recognized |
|
412
|
|
|
|
|
|
|
by any implementation: |
|
413
|
|
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|
|
|
|
|
|
414
|
|
|
|
|
|
|
-identifier query by the given identifier |
|
415
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|
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|
|
|
|
-name query by the given name |
|
416
|
|
|
|
|
|
|
|
|
417
|
|
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|
|
|
|
=cut |
|
418
|
|
|
|
|
|
|
|
|
419
|
|
|
|
|
|
|
sub find_terms{ |
|
420
|
0
|
|
|
0
|
1
|
|
my $self = shift; |
|
421
|
0
|
|
|
|
|
|
my %params = @_; |
|
422
|
0
|
|
|
|
|
|
@params{ map { lc $_; } keys %params } = values %params; # lowercase keys |
|
|
0
|
|
|
|
|
|
|
|
423
|
|
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|
424
|
|
|
|
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|
|
my @terms = grep { |
|
425
|
0
|
|
|
|
|
|
my $ok = exists($params{-identifier}) ? |
|
426
|
0
|
0
|
|
|
|
|
$_->identifier() eq $params{-identifier} : 1; |
|
427
|
|
|
|
|
|
|
$ok && ((! exists($params{-name})) || |
|
428
|
0
|
0
|
0
|
|
|
|
($_->name() eq $params{-name})); |
|
429
|
|
|
|
|
|
|
} $self->get_all_terms(); |
|
430
|
0
|
|
|
|
|
|
return @terms; |
|
431
|
|
|
|
|
|
|
} |
|
432
|
|
|
|
|
|
|
|
|
433
|
|
|
|
|
|
|
=head1 Experimental API method proposals |
|
434
|
|
|
|
|
|
|
|
|
435
|
|
|
|
|
|
|
Ontologies are a very new domain in bioperl, and we are not sure yet |
|
436
|
|
|
|
|
|
|
what we will want to do on and with ontologies in which |
|
437
|
|
|
|
|
|
|
situation. The methods from here on downwards are solely API |
|
438
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descriptions to solicit comment and feedback; the chance of any of |
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439
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those being actually implemented already is very slim. |
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440
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441
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Disclaimer: As long as an API method stays in this section, it is |
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442
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subject to change, possibly even radical change or complete |
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443
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deletion. If it's not implemented yet (most likely it isn't), |
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444
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implement yourself at your own risk. |
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445
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446
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So far for the disclaimer. The reason the API description is here, |
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447
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however, is to solicit feedback. Please feel encouraged to share your |
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448
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opinion, regardless of what it is (a notable difference of this API |
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449
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method to others is that there is actually no working code behind it |
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450
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- so the defense line is non-existent for practical purposes). |
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451
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452
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=cut |
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453
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454
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=head2 common_ancestor_path |
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455
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456
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Title : common_ancestor_path |
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457
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Usage : |
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458
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Function: Get the paths from two terms A and B to term C, such that |
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459
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there is no other term D to which A and B would have a shorter |
|
460
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path, provided there is a term C to which both A and B are |
|
461
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connected by a path. |
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462
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463
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Note that the path to the common ancestor between A and A |
|
464
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exists, has distance zero, and predicate "identity". |
|
465
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466
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The search for the common ancestor C can be further |
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467
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constrained by supplying a predicate term. If supplied, the |
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468
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predicates of the two paths (A,C) and (B,C) must have a |
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469
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common ancestor identical to the predicate, or that has a |
|
470
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path to the predicate. |
|
471
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472
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Example : |
|
473
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Returns : The path of the first term to the common ancestor in scalar |
|
474
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context, and both paths in list context. Paths are |
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475
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Bio::Ontology::PathI compliant objects. |
|
476
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Args : The two terms (Bio::Ontology::TermI objects), and optionally |
|
477
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a constraining common predicate (Bio::Ontology::TermI object). |
|
478
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The latter may also be given as a scalar, in which case it |
|
479
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is treated as a boolean that, if TRUE, means that the two paths |
|
480
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must have identical predicates in order to be returned. |
|
481
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|
482
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=cut |
|
483
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|
484
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sub common_ancestor_path{ |
|
485
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0
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0
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1
|
|
return shift->throw_not_implemented(); |
|
486
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} |
|
487
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|
488
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1; |