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package WWW::Search::PharmGKB; |
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22446
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use SOAP::Lite; |
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import SOAP::Data 'type'; |
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use English; |
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use Carp; |
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use vars qw($VERSION); |
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use Data::Dumper; |
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$VERSION = '2.01'; |
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sub new { |
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my $class = shift; |
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my $self = bless { |
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proxy => 'http://www.pharmgkb.org/services/PharmGKBItem', |
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uri => 'PharmGKBItem', |
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readable => 1, |
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}, |
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$class; |
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return $self; |
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} |
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sub gene_search { |
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my $self = shift; |
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my($gene) = @_; |
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my $result_obj = {}; |
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my $pharm_ids = $self->_search($gene, 'Gene'); |
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if($pharm_ids) { |
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foreach my $gene_id(@{$pharm_ids}) { |
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my $local_hash = {}; |
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my $soap_service = SOAP::Lite |
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-> readable ($self->{readable}) |
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-> uri($self->{uri}) |
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-> proxy($self->{proxy}) |
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-> searchGene ($gene_id); |
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my $search_result = $soap_service->result; |
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$local_hash->{'alternate_names'} = ''; |
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$local_hash->{'drugs'} = ''; |
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$local_hash->{'diseases'} = ''; |
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$local_hash->{'phenotypes'} = ''; |
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$local_hash->{'pathways'} = ''; |
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$local_hash->{'alternate_symbols'} = ''; |
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$local_hash->{'name'} = ''; |
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$local_hash->{symbol} = ''; |
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my @pathways = (); |
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if($search_result->{'geneRelatedPathways'}) { |
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my $pathway_result = $search_result->{'geneRelatedPathways'}; |
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for(my $i = 0; $i
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push(@pathways, {$pathway_result->[$i] => $pathway_result->[$i+1]}); |
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} |
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} |
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$local_hash->{'pathways'} = \@pathways; |
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if($search_result->{geneName}) { |
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$local_hash->{name} = $search_result->{geneName}; |
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} |
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if($search_result->{geneSymbol}) { |
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$local_hash->{symbol} = $search_result->{geneSymbol}; |
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} |
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if($search_result->{'geneAlternateNames'}) { |
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$local_hash->{'alternate_names'} = $search_result->{'geneAlternateNames'}; |
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} |
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if($search_result->{'geneRelatedDrugs'}) { |
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$local_hash->{'drugs'} = $search_result->{'geneRelatedDrugs'}; |
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} |
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if($search_result->{'geneRelatedDiseases'}) { |
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$local_hash->{'diseases'} = $search_result->{'geneRelatedDiseases'}; |
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} |
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if($search_result->{'geneAlternateSymbols'}) { |
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$local_hash->{'alternate_symbols'} = $search_result->{'geneAlternateSymbols'}; |
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} |
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if($search_result->{'geneRelatedPhenotypeDatasets'}) { |
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$local_hash->{'phenotypes'} = $search_result->{'geneRelatedPhenotypeDatasets'}; |
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} |
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$result_obj->{$gene_id} = $local_hash; |
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} |
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} |
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else { |
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print "Gene $gene was not found in PharmGKB!\n"; |
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} |
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return $result_obj; |
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} |
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sub disease_search { |
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my $self = shift; |
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my($disease) = @_; |
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my $result_obj = {}; |
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my $pharm_ids; |
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if($disease) { |
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$pharm_ids = $self->_search($disease, 'Disease'); |
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} |
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else { |
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print "\'$disease\' is weird. I can't search that\n"; |
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return 0; |
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} |
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102
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if($pharm_ids) { |
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foreach my $disease_id(@{$pharm_ids}) { |
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my $local_hash = {}; |
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my $soap_service = SOAP::Lite |
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-> readable (1) |
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-> uri($self->{uri}) |
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-> proxy($self->{proxy}) |
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-> searchDisease ($disease_id); |
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my $search_result = $soap_service->result; |
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$local_hash->{'names'} = ''; |
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$local_hash->{'drugs'} = ''; |
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$local_hash->{'genes'} = ''; |
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$local_hash->{'phenotypes'} = ''; |
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$local_hash->{'pathways'} = ''; |
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120
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my @pathways = (); |
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if($search_result->{'diseaseRelatedPathways'}) { |
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my $pathway_result = $search_result->{'diseaseRelatedPathways'}; |
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for(my $i = 0; $i
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push(@pathways, {$pathway_result->[$i] => $pathway_result->[$i+1]}); |
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} |
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} |
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$local_hash->{'pathways'} = \@pathways; |
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if($search_result->{'diseaseAlternateNames'}) { |
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$local_hash->{'names'} = $search_result->{'diseaseAlternateNames'}; |
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} |
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if($search_result->{'diseaseRelatedDrugs'}) { |
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$local_hash->{'drugs'} = $search_result->{'diseaseRelatedDrugs'}; |
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} |
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if($search_result->{'diseaseRelatedGenes'}) { |
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$local_hash->{'genes'} = $search_result->{'diseaseRelatedGenes'}; |
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} |
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if($search_result->{'diseaseRelatedPhenotypeDatasets'}) { |
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$local_hash->{'phenotypes'} = $search_result->{'diseaseRelatedPhenotypeDatasets'}; |
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} |
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142
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$result_obj->{$disease_id} = $local_hash; |
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} |
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} |
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else { |
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print "Disease $disease was not found in PharmGKB!\n"; |
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} |
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return $result_obj; |
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} |
150
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151
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sub drug_search { |
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my $self = shift; |
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my($drug) = @_; |
154
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my $result_obj = {}; |
155
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my $pharm_ids; |
156
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if($drug) { |
157
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$pharm_ids = $self->_search($drug, 'Drug'); |
158
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} |
159
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else { |
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print "\'$drug\' is weird. I can't search that\n"; |
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return 0; |
162
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} |
163
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if($pharm_ids) { |
164
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foreach my $drug_id(@{$pharm_ids}) { |
165
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my $local_hash = {}; |
166
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my $soap_service = SOAP::Lite |
167
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-> readable (1) |
168
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-> uri($self->{uri}) |
169
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-> proxy($self->{proxy}) |
170
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-> searchDrug ($drug_id); |
171
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172
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my $search_result = $soap_service->result; |
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$local_hash->{'generic_names'} = ''; |
174
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$local_hash->{'trade_names'} = ''; |
175
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$local_hash->{'category'} = ''; |
176
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$local_hash->{'classification'} = ''; |
177
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$local_hash->{'genes'} = ''; |
178
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$local_hash->{'diseases'} = ''; |
179
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$local_hash->{'phenotypes'} = ''; |
180
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$local_hash->{'pathways'} = ''; |
181
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$local_hash->{'name'} = ''; |
182
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my @pathways = (); |
183
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if($search_result->{'drugRelatedPathways'}) { |
184
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my $pathway_result = $search_result->{'drugRelatedPathways'}; |
185
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186
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for(my $i = 0; $i < scalar(@{$pathway_result}); $i+= 2) { |
187
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push(@pathways, {$pathway_result->[$i] => $pathway_result->[$i+1]}); |
188
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} |
189
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} |
190
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$local_hash->{'pathways'} = \@pathways; |
191
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if($search_result->{'drugName'}) { |
192
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$local_hash->{'name'} = $search_result->{'drugName'}; |
193
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} |
194
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if($search_result->{'drugGenericNames'}) { |
195
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$local_hash->{'generic_names'} = $search_result->{'drugGenericNames'}; |
196
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} |
197
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if($search_result->{'drugTradeNames'}) { |
198
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$local_hash->{'trade_names'} = $search_result->{'drugTradeNames'}; |
199
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} |
200
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if($search_result->{'drugCategory'}) { |
201
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$local_hash->{'category'} = $search_result->{'drugCategory'}; |
202
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} |
203
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if($search_result->{'drugVaClassifications'}){ |
204
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$local_hash->{'classification'} = $search_result->{'drugVaClassifications'}; |
205
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} |
206
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if($search_result->{'drugRelatedGenes'}) { |
207
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$local_hash->{'genes'} = $search_result->{'drugRelatedGenes'}; |
208
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} |
209
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if($search_result->{'drugRelatedDiseases'}) { |
210
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$local_hash->{'diseases'} = $search_result->{'drugRelatedDiseases'}; |
211
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} |
212
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if($search_result->{'drugRelatedPhenotypeDatasets'}) { |
213
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$local_hash->{'phenotypes'} = $search_result->{'drugRelatedPhenotypeDatasets'}; |
214
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} |
215
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216
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$result_obj->{$drug_id} = $local_hash; |
217
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} |
218
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} |
219
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else { |
220
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print "Drug $drug was not found in PharmGKB!\n"; |
221
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} |
222
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return $result_obj; |
223
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} |
224
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225
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sub publication_search { |
226
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227
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my $self = shift; |
228
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|
my($search_term) = @_; |
229
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|
my $pharm_ids; |
230
|
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|
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|
my $result_obj = {}; |
231
|
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|
|
|
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|
if($search_term) { |
232
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|
$pharm_ids = $self->_search($search_term, 'Publication'); |
233
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|
} |
234
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|
else { |
235
|
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|
print "\'$search_term\' is weird. I can't search that\n"; |
236
|
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|
return 0; |
237
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|
} |
238
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|
if($pharm_ids) { |
239
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|
foreach my $id(@{$pharm_ids}) { |
240
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|
my $local_hash = {}; |
241
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|
my $soap_service = SOAP::Lite |
242
|
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|
-> readable ($self->{readable}) |
243
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|
-> uri($self->{uri}) |
244
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|
-> proxy($self->{proxy}) |
245
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|
-> searchPublication ($id); |
246
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247
|
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|
|
my $search_result = $soap_service->result; |
248
|
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|
$local_hash->{'grant_id'} = ''; |
249
|
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|
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|
$local_hash->{'journal'} = ''; |
250
|
|
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|
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|
$local_hash->{'title'} = ''; |
251
|
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|
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|
$local_hash->{'month'} = ''; |
252
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|
$local_hash->{'abstract'} = ''; |
253
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|
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|
|
$local_hash->{'authors'} = ''; |
254
|
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|
$local_hash->{'volume'} = ''; |
255
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|
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|
|
$local_hash->{'page'} = ''; |
256
|
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|
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|
|
$local_hash->{'cross_reference'} = ''; |
257
|
|
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|
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|
|
$local_hash->{'year'} = ''; |
258
|
|
|
|
|
|
|
if($search_result) { |
259
|
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|
|
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|
|
if($search_result->{publicationGrantIds}) { |
260
|
|
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|
|
|
|
$local_hash->{'grants_id'} = $search_result->{publicationGrantIds}; |
261
|
|
|
|
|
|
|
} |
262
|
|
|
|
|
|
|
if($search_result->{publicationJournal}) { |
263
|
|
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|
|
|
|
$local_hash->{journal} = $search_result->{publicationJournal}; |
264
|
|
|
|
|
|
|
} |
265
|
|
|
|
|
|
|
if($search_result->{publicationName}) { |
266
|
|
|
|
|
|
|
$local_hash->{title} = $search_result->{publicationName}; |
267
|
|
|
|
|
|
|
} |
268
|
|
|
|
|
|
|
if($search_result->{publicationMonth}) { |
269
|
|
|
|
|
|
|
$local_hash->{month} = $search_result->{publicationMonth}; |
270
|
|
|
|
|
|
|
} |
271
|
|
|
|
|
|
|
if($search_result->{publicationAbstract}) { |
272
|
|
|
|
|
|
|
$local_hash->{'abstract'} = $search_result->{publicationAbstract}; |
273
|
|
|
|
|
|
|
} |
274
|
|
|
|
|
|
|
if($search_result->{publicationAuthors}) { |
275
|
|
|
|
|
|
|
$local_hash->{authors} = $search_result->{publicationAuthors}; |
276
|
|
|
|
|
|
|
} |
277
|
|
|
|
|
|
|
if($search_result->{publicationVolume}) { |
278
|
|
|
|
|
|
|
$local_hash->{volume} = $search_result->{publicationVolume}; |
279
|
|
|
|
|
|
|
} |
280
|
|
|
|
|
|
|
if($search_result->{publicationPage}) { |
281
|
|
|
|
|
|
|
$local_hash->{page} = $search_result->{publicationPage}; |
282
|
|
|
|
|
|
|
} |
283
|
|
|
|
|
|
|
if($search_result->{publicationAnnotationCrossReference}) { |
284
|
|
|
|
|
|
|
my $references = $search_result->{publicationAnnotationCrossReference}; |
285
|
|
|
|
|
|
|
my @references_array = (); |
286
|
|
|
|
|
|
|
for(my $i=0; $i < scalar(@{$references});$i+=2) { |
287
|
|
|
|
|
|
|
push(@references_array, {$references->[$i] => $references->[$i+1]}); |
288
|
|
|
|
|
|
|
} |
289
|
|
|
|
|
|
|
$local_hash->{'cross_reference'} = \@references_array; |
290
|
|
|
|
|
|
|
} |
291
|
|
|
|
|
|
|
if($search_result->{publicationYear}) { |
292
|
|
|
|
|
|
|
$local_hash->{year} = $search_result->{publicationYear}; |
293
|
|
|
|
|
|
|
} |
294
|
|
|
|
|
|
|
} |
295
|
|
|
|
|
|
|
$result_obj->{$id} = $local_hash; |
296
|
|
|
|
|
|
|
} |
297
|
|
|
|
|
|
|
} |
298
|
|
|
|
|
|
|
else { |
299
|
|
|
|
|
|
|
print "No results found for $search_term\n"; |
300
|
|
|
|
|
|
|
} |
301
|
|
|
|
|
|
|
return $result_obj; |
302
|
|
|
|
|
|
|
} |
303
|
|
|
|
|
|
|
|
304
|
|
|
|
|
|
|
|
305
|
|
|
|
|
|
|
sub _search { |
306
|
|
|
|
|
|
|
my $self = shift; |
307
|
|
|
|
|
|
|
my($search_term, $key) = @_; |
308
|
|
|
|
|
|
|
my @pharm_id = (); |
309
|
|
|
|
|
|
|
|
310
|
|
|
|
|
|
|
my $soap_service = SOAP::Lite |
311
|
|
|
|
|
|
|
-> readable ($self->{readable}) |
312
|
|
|
|
|
|
|
-> uri('SearchService') |
313
|
|
|
|
|
|
|
-> proxy('http://www.pharmgkb.org/services/SearchService') |
314
|
|
|
|
|
|
|
-> search ($search_term); |
315
|
|
|
|
|
|
|
my $search_result = $soap_service->result; |
316
|
|
|
|
|
|
|
foreach my $search_obj(@{$search_result}) { |
317
|
|
|
|
|
|
|
if($search_obj->[1] =~ m/$key/ig) { |
318
|
|
|
|
|
|
|
push(@pharm_id, $search_obj->[0]); |
319
|
|
|
|
|
|
|
} |
320
|
|
|
|
|
|
|
} |
321
|
|
|
|
|
|
|
return \@pharm_id; |
322
|
|
|
|
|
|
|
|
323
|
|
|
|
|
|
|
} |
324
|
|
|
|
|
|
|
|
325
|
|
|
|
|
|
|
1; |
326
|
|
|
|
|
|
|
|
327
|
|
|
|
|
|
|
|
328
|
|
|
|
|
|
|
=head1 NAME |
329
|
|
|
|
|
|
|
|
330
|
|
|
|
|
|
|
WWW::Search::PharmGKB - Search and retrieve information from the PharmGKB database |
331
|
|
|
|
|
|
|
|
332
|
|
|
|
|
|
|
=head1 VERSION |
333
|
|
|
|
|
|
|
|
334
|
|
|
|
|
|
|
Version 2.00 |
335
|
|
|
|
|
|
|
|
336
|
|
|
|
|
|
|
=cut |
337
|
|
|
|
|
|
|
|
338
|
|
|
|
|
|
|
=head1 SYNOPSIS |
339
|
|
|
|
|
|
|
|
340
|
|
|
|
|
|
|
use WWW::Search::PharmGKB; |
341
|
|
|
|
|
|
|
use Data::Dumper; |
342
|
|
|
|
|
|
|
my $foo = WWW::Search::PharmGKB->new(); |
343
|
|
|
|
|
|
|
my $search_result = $foo->gene_search('CYP2D6'); |
344
|
|
|
|
|
|
|
print Dumper $search_result; |
345
|
|
|
|
|
|
|
|
346
|
|
|
|
|
|
|
|
347
|
|
|
|
|
|
|
=head1 METHODS |
348
|
|
|
|
|
|
|
|
349
|
|
|
|
|
|
|
=head2 new |
350
|
|
|
|
|
|
|
|
351
|
|
|
|
|
|
|
=head3 Usage: |
352
|
|
|
|
|
|
|
|
353
|
|
|
|
|
|
|
$foo = WWW::Search::PharmGKB->new(); |
354
|
|
|
|
|
|
|
or |
355
|
|
|
|
|
|
|
$foo = new WWW::Search::PharmGKB; |
356
|
|
|
|
|
|
|
|
357
|
|
|
|
|
|
|
=head3 Returns: |
358
|
|
|
|
|
|
|
|
359
|
|
|
|
|
|
|
Self |
360
|
|
|
|
|
|
|
|
361
|
|
|
|
|
|
|
=cut |
362
|
|
|
|
|
|
|
|
363
|
|
|
|
|
|
|
=head2 gene_search |
364
|
|
|
|
|
|
|
|
365
|
|
|
|
|
|
|
=head3 Usage: |
366
|
|
|
|
|
|
|
|
367
|
|
|
|
|
|
|
$foo->gene_search(); |
368
|
|
|
|
|
|
|
|
369
|
|
|
|
|
|
|
=head3 Returns: |
370
|
|
|
|
|
|
|
|
371
|
|
|
|
|
|
|
A referenced hash. The keys are 'drugs', 'name', 'symbol', 'pathways', |
372
|
|
|
|
|
|
|
'drugs', 'diseases', 'phenotypes', 'alternate_names', 'alternate_symbols' |
373
|
|
|
|
|
|
|
|
374
|
|
|
|
|
|
|
=head3 Note: |
375
|
|
|
|
|
|
|
|
376
|
|
|
|
|
|
|
all the keys contain referenced arrays as values. In the pathway value, |
377
|
|
|
|
|
|
|
the array has key => value pairs 'pathway' => 'pharmGKB URL' as elements. |
378
|
|
|
|
|
|
|
All other keys have referenced array of PharmGKB IDs. |
379
|
|
|
|
|
|
|
|
380
|
|
|
|
|
|
|
=cut |
381
|
|
|
|
|
|
|
|
382
|
|
|
|
|
|
|
=head2 disease_search |
383
|
|
|
|
|
|
|
|
384
|
|
|
|
|
|
|
=head3 Usage: |
385
|
|
|
|
|
|
|
|
386
|
|
|
|
|
|
|
$foo->disease_search(); |
387
|
|
|
|
|
|
|
|
388
|
|
|
|
|
|
|
=head3 Returns: |
389
|
|
|
|
|
|
|
|
390
|
|
|
|
|
|
|
A referenced hash of pharmGKB IDs. Each ID contains 'drugs', 'names', 'pathways', 'drugs', |
391
|
|
|
|
|
|
|
'genes', 'phenotypes'. |
392
|
|
|
|
|
|
|
|
393
|
|
|
|
|
|
|
=head3 Note: |
394
|
|
|
|
|
|
|
|
395
|
|
|
|
|
|
|
all the keys contain referenced arrays as values. in the pathway value, |
396
|
|
|
|
|
|
|
the array has key => value pairs 'pathway' => 'pharmGKB URL' as elements. |
397
|
|
|
|
|
|
|
All other keys have referenced array of PharmGKB IDs. |
398
|
|
|
|
|
|
|
=cut |
399
|
|
|
|
|
|
|
|
400
|
|
|
|
|
|
|
=head2 drug_search |
401
|
|
|
|
|
|
|
|
402
|
|
|
|
|
|
|
=head3 Usage: |
403
|
|
|
|
|
|
|
|
404
|
|
|
|
|
|
|
$foo->drug_search(); |
405
|
|
|
|
|
|
|
|
406
|
|
|
|
|
|
|
=head3 Returns: |
407
|
|
|
|
|
|
|
|
408
|
|
|
|
|
|
|
A referenced hash of pharmGKB IDs. Each ID contains 'diseases', 'generic_names', 'trade_names', |
409
|
|
|
|
|
|
|
'pathways', 'genes', 'phenotypes', 'category', 'classification' |
410
|
|
|
|
|
|
|
|
411
|
|
|
|
|
|
|
=head3 Note: |
412
|
|
|
|
|
|
|
|
413
|
|
|
|
|
|
|
all the keys contain referenced arrays as values. in the pathway value, |
414
|
|
|
|
|
|
|
the array has key => value pairs 'pathway' => 'pharmGKB URL' as elements. |
415
|
|
|
|
|
|
|
All other keys have referenced array of PharmGKB IDs. |
416
|
|
|
|
|
|
|
=cut |
417
|
|
|
|
|
|
|
|
418
|
|
|
|
|
|
|
=head2 publication_search |
419
|
|
|
|
|
|
|
|
420
|
|
|
|
|
|
|
=head3 Usage: |
421
|
|
|
|
|
|
|
|
422
|
|
|
|
|
|
|
$foo->publication_search(); |
423
|
|
|
|
|
|
|
|
424
|
|
|
|
|
|
|
=head3 Returns: |
425
|
|
|
|
|
|
|
|
426
|
|
|
|
|
|
|
A referenced hash of pharmGKB IDs. Each ID contains 'authors', 'page', |
427
|
|
|
|
|
|
|
'volume', 'month', 'grant_id', 'cross_reference', 'title', 'abstract', 'year', |
428
|
|
|
|
|
|
|
'journal'. |
429
|
|
|
|
|
|
|
|
430
|
|
|
|
|
|
|
=cut |
431
|
|
|
|
|
|
|
|
432
|
|
|
|
|
|
|
=head1 AUTHOR |
433
|
|
|
|
|
|
|
|
434
|
|
|
|
|
|
|
Arun Venkataraman, C<< >> |
435
|
|
|
|
|
|
|
|
436
|
|
|
|
|
|
|
=head1 BUGS |
437
|
|
|
|
|
|
|
|
438
|
|
|
|
|
|
|
Please report any bugs or feature requests to C, or through |
439
|
|
|
|
|
|
|
the web interface at L. I will be notified, and then you'll |
440
|
|
|
|
|
|
|
automatically be notified of progress on your bug as I make changes. |
441
|
|
|
|
|
|
|
|
442
|
|
|
|
|
|
|
|
443
|
|
|
|
|
|
|
|
444
|
|
|
|
|
|
|
|
445
|
|
|
|
|
|
|
=head1 SUPPORT |
446
|
|
|
|
|
|
|
|
447
|
|
|
|
|
|
|
You can find documentation for this module with the perldoc command. |
448
|
|
|
|
|
|
|
|
449
|
|
|
|
|
|
|
perldoc WWW::Search::PharmGKB |
450
|
|
|
|
|
|
|
|
451
|
|
|
|
|
|
|
You can also look for information at: |
452
|
|
|
|
|
|
|
|
453
|
|
|
|
|
|
|
=over 4 |
454
|
|
|
|
|
|
|
|
455
|
|
|
|
|
|
|
=item * RT: CPAN's request tracker |
456
|
|
|
|
|
|
|
|
457
|
|
|
|
|
|
|
L |
458
|
|
|
|
|
|
|
|
459
|
|
|
|
|
|
|
=item * AnnoCPAN: Annotated CPAN documentation |
460
|
|
|
|
|
|
|
|
461
|
|
|
|
|
|
|
L |
462
|
|
|
|
|
|
|
|
463
|
|
|
|
|
|
|
=item * CPAN Ratings |
464
|
|
|
|
|
|
|
|
465
|
|
|
|
|
|
|
L |
466
|
|
|
|
|
|
|
|
467
|
|
|
|
|
|
|
=item * Search CPAN |
468
|
|
|
|
|
|
|
|
469
|
|
|
|
|
|
|
L |
470
|
|
|
|
|
|
|
|
471
|
|
|
|
|
|
|
=back |
472
|
|
|
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473
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You can contact the author for any issues or suggestions you come accross using this module. |
474
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475
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=head1 ACKNOWLEDGEMENTS |
476
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477
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This module is based on the perl client written by Andrew MacBride (andrew@helix.stanford.edu) for PharmGKB's web services. |
478
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479
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=head1 COPYRIGHT & LICENSE |
480
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481
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Copyright 2010 Arun Venkataraman C, all rights reserved. |
482
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483
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This program is free software; you can redistribute it and/or modify it |
484
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under the same terms as Perl itself. |
485
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486
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487
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=cut |