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package Bio::Tools::Phylo::PAML::Result; |
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$Bio::Tools::Phylo::PAML::Result::VERSION = '1.7.2'; |
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use utf8; |
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use strict; |
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use warnings; |
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use base qw(Bio::Root::Root Bio::AnalysisResultI); |
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714
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# ABSTRACT: A PAML result set object |
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# AUTHOR: Jason Stajich |
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# AUTHOR: Aaron Mackey |
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# OWNER: Jason Stajich |
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# OWNER: Aaron Mackey |
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# LICENSE: Perl_5 |
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# AUTHOR: Albert Vilella |
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sub new { |
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1
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my($class,@args) = @_; |
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87
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my $self = $class->SUPER::new(@args); |
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686
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my ($trees,$mlmat,$seqs,$ngmatrix, |
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25
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$codonpos,$codonfreq,$version, |
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26
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$model,$patterns, $stats, |
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27
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$aafreq, $aadistmat, |
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28
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$aamldistmat, |
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29
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$ntfreqs, $seqfile, $kappa_mat, $alpha_mat, |
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$NSSitesresults,$input_params,$rst,$rst_persite,$rst_trees ) = |
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$self->_rearrange([qw |
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(TREES MLMATRIX |
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SEQS NGMATRIX |
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34
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CODONPOS CODONFREQ |
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35
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VERSION MODEL PATTERNS |
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STATS AAFREQ AADISTMAT |
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37
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AAMLDISTMAT |
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38
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NTFREQ SEQFILE |
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39
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KAPPA_DISTMAT |
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40
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ALPHA_DISTMAT |
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41
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NSSITESRESULTS |
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42
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INPUT_PARAMS |
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43
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RST RST_PERSITE RST_TREES)], |
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44
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@args); |
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45
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20
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1725
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$self->reset_seqs; |
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46
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20
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100
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53
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if( $trees ) { |
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47
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3
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50
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18
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if(ref($trees) !~ /ARRAY/i ) { |
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48
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0
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0
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$self->warn("Must provide a valid array reference to initialize trees"); |
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49
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} else { |
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50
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3
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9
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foreach my $t ( @$trees ) { |
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51
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3
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13
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$self->add_tree($t); |
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52
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} |
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53
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} |
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54
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} |
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55
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20
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37
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$self->{'_treeiterator'} = 0; |
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56
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57
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20
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100
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45
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if( $mlmat ) { |
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58
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10
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50
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52
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if( ref($mlmat) !~ /ARRAY/i ) { |
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59
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0
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0
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$self->warn("Must provide a valid array reference to initialize MLmatrix"); |
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60
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} else { |
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61
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10
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31
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$self->set_MLmatrix($mlmat); |
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62
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} |
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63
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} |
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64
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20
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100
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52
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if( $seqs ) { |
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65
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15
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50
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51
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if( ref($seqs) !~ /ARRAY/i ) { |
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66
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0
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0
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$self->warn("Must provide a valid array reference to initialize seqs"); |
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67
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} else { |
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68
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15
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42
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foreach my $s ( @$seqs ) { |
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69
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80
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139
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$self->add_seq($s); |
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70
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} |
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71
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} |
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72
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} |
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73
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20
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100
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51
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if( $ngmatrix ) { |
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74
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16
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50
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61
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if( ref($ngmatrix) !~ /ARRAY/i ) { |
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75
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0
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0
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$self->warn("Must provide a valid array reference to initialize NGmatrix"); |
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76
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} else { |
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77
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16
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47
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$self->set_NGmatrix($ngmatrix); |
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78
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} |
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79
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} |
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80
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20
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100
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60
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if( $codonfreq ) { |
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81
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8
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50
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36
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if( ref($codonfreq) =~ /ARRAY/i ) { |
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82
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8
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31
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$self->set_CodonFreqs($codonfreq); |
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83
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} else { |
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84
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0
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0
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$self->warn("Must provide a valid array reference to initialize codonfreq"); |
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85
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} |
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86
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} |
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87
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88
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20
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100
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49
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if( $codonpos ) { |
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89
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14
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50
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44
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if( ref($codonpos) !~ /ARRAY/i ) { |
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90
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0
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0
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$self->warn("Must provide a valid array reference to initialize codonpos"); |
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91
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} else { |
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92
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14
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84
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$self->set_codon_pos_basefreq(@$codonpos); |
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93
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} |
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94
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} |
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95
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96
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20
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100
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82
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$self->version($version) if defined $version; |
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97
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20
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50
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79
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$self->seqfile($seqfile) if defined $seqfile; |
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98
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20
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100
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78
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$self->model($model) if defined $model; |
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99
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20
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100
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44
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if( defined $patterns ) { |
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100
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18
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50
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55
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if( ref($patterns) =~ /HASH/i ) { |
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101
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18
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41
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$self->patterns($patterns); |
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102
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} else { |
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103
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0
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0
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$self->warn("Must provide a valid array reference to initialize patterns"); |
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104
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} |
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105
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} |
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106
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107
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20
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50
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$self->{'_aafreqs'} = {}; |
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108
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20
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100
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52
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if( $aafreq ) { |
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109
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2
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50
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7
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if( ref($aafreq) =~ /HASH/i ) { |
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110
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2
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5
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$self->set_AAFreqs($aafreq); |
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111
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} else { |
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112
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0
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0
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$self->warn("Must provide a valid hash reference to initialize aafreq"); |
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113
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} |
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114
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} |
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115
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20
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100
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58
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if( $stats ) { |
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116
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4
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50
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14
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if( ref($stats) =~ /HASH/i ) { |
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117
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4
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49
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while( my ($stat,$val) = each %$stats) { |
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118
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11
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24
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$self->add_stat($stat,$val); |
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119
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} |
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120
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} else { |
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121
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0
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0
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$self->warn("Must provide a valid hash reference initialize stats"); |
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122
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} |
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123
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} |
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124
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20
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100
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45
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$self->set_AADistMatrix($aadistmat) if defined $aadistmat; |
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125
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20
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100
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43
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$self->set_AAMLDistMatrix($aamldistmat) if defined $aamldistmat; |
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126
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127
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20
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100
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45
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if( defined $NSSitesresults ) { |
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128
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5
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50
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27
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if( ref($NSSitesresults) !~ /ARRAY/i ) { |
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129
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0
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0
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$self->warn("expected an arrayref for -NSSitesresults"); |
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130
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} else { |
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131
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5
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12
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foreach my $m ( @$NSSitesresults ) { |
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132
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9
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22
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$self->add_NSSite_result($m); |
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133
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} |
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134
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} |
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135
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} |
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136
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137
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20
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35
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$self->{'_ntfreqs'} = {}; |
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138
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20
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100
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43
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if( $ntfreqs ) { |
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139
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2
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50
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8
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if( ref($ntfreqs) =~ /HASH/i ) { |
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140
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2
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5
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$self->set_NTFreqs($ntfreqs); |
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141
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} else { |
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142
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0
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0
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$self->warn("Must provide a valid hash reference to initialize ntfreq"); |
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143
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} |
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144
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} |
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145
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146
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20
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100
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42
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if( $kappa_mat ) { |
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147
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2
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8
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$self->set_KappaMatrix($kappa_mat); |
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148
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} |
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149
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20
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100
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36
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if( $alpha_mat ) { |
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150
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2
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9
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$self->set_AlphaMatrix($alpha_mat); |
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151
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} |
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152
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153
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20
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100
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34
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if( $input_params ) { |
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154
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8
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50
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27
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if( ref($input_params) !~ /HASH/i ) { |
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155
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0
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0
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$self->warn("Must provide a valid hash object for input_params\n"); |
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156
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} else { |
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157
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8
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38
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while( my ($p,$v) = each %$input_params ) { |
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158
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10
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35
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$self->set_input_parameter($p,$v); |
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159
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} |
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160
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} |
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161
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162
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} |
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163
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20
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68
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$self->reset_rst_seqs; |
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164
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20
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100
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46
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if( $rst ) { |
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165
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1
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50
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5
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if( ref($rst) =~ /ARRAY/i ) { |
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166
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1
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3
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for ( @$rst ) { |
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167
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20
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29
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$self->add_rst_seq($_); |
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168
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} |
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169
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} else { |
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170
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0
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0
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$self->warn("Need a valid array ref for -rst option\n"); |
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171
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} |
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172
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} |
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173
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20
|
100
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45
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if( defined $rst_persite ) { |
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174
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1
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4
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$self->set_rst_persite($rst_persite); |
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175
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} |
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176
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20
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59
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$self->reset_rst_trees; |
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177
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20
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100
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42
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if( $rst_trees ) { |
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178
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1
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50
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6
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if( ref($rst_trees) =~ /ARRAY/i ) { |
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179
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1
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20
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for ( @$rst_trees ) { |
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180
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1
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4
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$self->add_rst_tree($_); |
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181
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} |
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182
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} else { |
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183
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0
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0
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$self->warn("Need a valid array ref for -rst_trees option\n"); |
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184
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} |
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185
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} |
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186
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187
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20
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|
196
|
return $self; |
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188
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} |
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189
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190
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191
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sub next_tree{ |
|
192
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0
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|
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0
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1
|
0
|
my ($self,@args) = @_; |
|
193
|
0
|
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0
|
|
|
0
|
return $self->{'_trees'}->[$self->{'_treeiterator'}++] || undef; |
|
194
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|
|
} |
|
195
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196
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197
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sub get_trees{ |
|
198
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2
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2
|
1
|
54
|
my ($self) = @_; |
|
199
|
2
|
50
|
|
|
|
4
|
return @{$self->{'_trees'} || []}; |
|
|
2
|
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12
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|
200
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} |
|
201
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202
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203
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sub rewind_tree_iterator { |
|
204
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0
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|
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0
|
1
|
0
|
shift->{'_treeiterator'} = 0; |
|
205
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} |
|
206
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207
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208
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|
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sub add_tree{ |
|
209
|
3
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3
|
1
|
8
|
my ($self,$tree) = @_; |
|
210
|
3
|
50
|
33
|
|
|
32
|
if( $tree && ref($tree) && $tree->isa('Bio::Tree::TreeI') ) { |
|
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33
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211
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3
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6
|
push @{$self->{'_trees'}},$tree; |
|
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3
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10
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212
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|
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} |
|
213
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3
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|
7
|
return scalar @{$self->{'_trees'}}; |
|
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3
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9
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214
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} |
|
215
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216
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217
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218
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|
sub set_MLmatrix{ |
|
219
|
10
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|
10
|
1
|
31
|
my ($self,$mat) = @_; |
|
220
|
10
|
50
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|
23
|
return unless ( defined $mat ); |
|
221
|
10
|
50
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|
38
|
if( ref($mat) !~ /ARRAY/i ) { |
|
222
|
0
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|
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|
|
0
|
$self->warn("Did not provide a valid 2D Array reference for set_MLmatrix"); |
|
223
|
0
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|
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|
|
0
|
return; |
|
224
|
|
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|
|
} |
|
225
|
10
|
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|
|
35
|
$self->{'_mlmatrix'} = $mat; |
|
226
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|
|
} |
|
227
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228
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|
229
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|
|
sub get_MLmatrix{ |
|
230
|
8
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|
|
8
|
1
|
1215
|
my ($self,@args) = @_; |
|
231
|
8
|
|
|
|
|
110
|
return $self->{'_mlmatrix'}; |
|
232
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|
|
} |
|
233
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|
234
|
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|
235
|
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|
|
sub set_NGmatrix{ |
|
236
|
16
|
|
|
16
|
1
|
41
|
my ($self,$mat) = @_; |
|
237
|
16
|
50
|
|
|
|
36
|
return unless ( defined $mat ); |
|
238
|
16
|
50
|
|
|
|
49
|
if( ref($mat) !~ /ARRAY/i ) { |
|
239
|
0
|
|
|
|
|
0
|
$self->warn("Did not provide a valid 2D Array reference for set_NGmatrix"); |
|
240
|
0
|
|
|
|
|
0
|
return; |
|
241
|
|
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|
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|
|
} |
|
242
|
16
|
|
|
|
|
40
|
$self->{'_ngmatrix'} = $mat; |
|
243
|
|
|
|
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|
|
} |
|
244
|
|
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|
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|
|
|
|
245
|
|
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|
|
|
|
246
|
|
|
|
|
|
|
sub get_NGmatrix{ |
|
247
|
9
|
|
|
9
|
1
|
38
|
my ($self,@args) = @_; |
|
248
|
9
|
|
|
|
|
47
|
return $self->{'_ngmatrix'}; |
|
249
|
|
|
|
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|
|
} |
|
250
|
|
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|
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|
|
251
|
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|
252
|
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|
|
253
|
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|
|
|
sub add_seq{ |
|
254
|
80
|
|
|
80
|
1
|
120
|
my ($self,$seq) = @_; |
|
255
|
80
|
50
|
|
|
|
146
|
if( $seq ) { |
|
256
|
80
|
50
|
|
|
|
195
|
unless( $seq->isa("Bio::PrimarySeqI") ) { |
|
257
|
0
|
|
|
|
|
0
|
$self->warn("Must provide a valid Bio::PrimarySeqI to add_seq"); |
|
258
|
0
|
|
|
|
|
0
|
return; |
|
259
|
|
|
|
|
|
|
} |
|
260
|
80
|
|
|
|
|
93
|
push @{$self->{'_seqs'}},$seq; |
|
|
80
|
|
|
|
|
179
|
|
|
261
|
|
|
|
|
|
|
} |
|
262
|
|
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|
|
|
|
|
263
|
|
|
|
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|
|
} |
|
264
|
|
|
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|
|
|
|
|
265
|
|
|
|
|
|
|
|
|
266
|
|
|
|
|
|
|
sub reset_seqs{ |
|
267
|
20
|
|
|
20
|
1
|
41
|
my ($self) = @_; |
|
268
|
20
|
|
|
|
|
50
|
$self->{'_seqs'} = []; |
|
269
|
|
|
|
|
|
|
} |
|
270
|
|
|
|
|
|
|
|
|
271
|
|
|
|
|
|
|
|
|
272
|
|
|
|
|
|
|
sub get_seqs{ |
|
273
|
5
|
|
|
5
|
1
|
2236
|
my ($self) = @_; |
|
274
|
5
|
|
|
|
|
8
|
return @{$self->{'_seqs'}}; |
|
|
5
|
|
|
|
|
18
|
|
|
275
|
|
|
|
|
|
|
} |
|
276
|
|
|
|
|
|
|
|
|
277
|
|
|
|
|
|
|
|
|
278
|
|
|
|
|
|
|
sub set_codon_pos_basefreq { |
|
279
|
14
|
|
|
14
|
1
|
36
|
my ($self,@codonpos) = @_; |
|
280
|
14
|
50
|
|
|
|
39
|
if( scalar @codonpos != 3 ) { |
|
281
|
0
|
|
|
|
|
0
|
$self->warn("invalid array to set_codon_pos_basefreq, must be an array of length 3"); |
|
282
|
0
|
|
|
|
|
0
|
return; |
|
283
|
|
|
|
|
|
|
} |
|
284
|
14
|
|
|
|
|
29
|
foreach my $pos ( @codonpos ) { |
|
285
|
42
|
50
|
33
|
|
|
178
|
if( ref($pos) !~ /HASH/i || |
|
286
|
|
|
|
|
|
|
! exists $pos->{'A'} ) { |
|
287
|
0
|
|
|
|
|
0
|
$self->warn("invalid array to set_codon_pos_basefreq, must be an array with hashreferences keyed on DNA bases, C,A,G,T"); |
|
288
|
|
|
|
|
|
|
} |
|
289
|
|
|
|
|
|
|
} |
|
290
|
14
|
|
|
|
|
38
|
$self->{'_codonposbasefreq'} = [@codonpos]; |
|
291
|
|
|
|
|
|
|
} |
|
292
|
|
|
|
|
|
|
|
|
293
|
|
|
|
|
|
|
|
|
294
|
|
|
|
|
|
|
sub get_codon_pos_basefreq{ |
|
295
|
1
|
|
|
1
|
1
|
7274
|
my ($self) = @_; |
|
296
|
1
|
|
|
|
|
2
|
return @{$self->{'_codonposbasefreq'}}; |
|
|
1
|
|
|
|
|
5
|
|
|
297
|
|
|
|
|
|
|
} |
|
298
|
|
|
|
|
|
|
|
|
299
|
|
|
|
|
|
|
|
|
300
|
|
|
|
|
|
|
sub version{ |
|
301
|
24
|
|
|
24
|
1
|
43
|
my $self = shift; |
|
302
|
24
|
100
|
|
|
|
75
|
$self->{'_version'} = shift if @_; |
|
303
|
24
|
|
|
|
|
71
|
return $self->{'_version'}; |
|
304
|
|
|
|
|
|
|
} |
|
305
|
|
|
|
|
|
|
|
|
306
|
|
|
|
|
|
|
|
|
307
|
|
|
|
|
|
|
sub seqfile{ |
|
308
|
20
|
|
|
20
|
1
|
32
|
my $self = shift; |
|
309
|
20
|
50
|
|
|
|
61
|
$self->{'_seqfile'} = shift if @_; |
|
310
|
20
|
|
|
|
|
36
|
return $self->{'_seqfile'}; |
|
311
|
|
|
|
|
|
|
} |
|
312
|
|
|
|
|
|
|
|
|
313
|
|
|
|
|
|
|
|
|
314
|
|
|
|
|
|
|
sub model{ |
|
315
|
27
|
|
|
27
|
1
|
2760
|
my $self = shift; |
|
316
|
|
|
|
|
|
|
|
|
317
|
27
|
100
|
|
|
|
71
|
return $self->{'_model'} = shift if @_; |
|
318
|
9
|
|
|
|
|
53
|
return $self->{'_model'}; |
|
319
|
|
|
|
|
|
|
} |
|
320
|
|
|
|
|
|
|
|
|
321
|
|
|
|
|
|
|
|
|
322
|
|
|
|
|
|
|
|
|
323
|
|
|
|
|
|
|
sub patterns{ |
|
324
|
20
|
|
|
20
|
1
|
47
|
my $self = shift; |
|
325
|
20
|
100
|
|
|
|
58
|
return $self->{'_patterns'} = shift if @_; |
|
326
|
2
|
|
|
|
|
7
|
return $self->{'_patterns'}; |
|
327
|
|
|
|
|
|
|
} |
|
328
|
|
|
|
|
|
|
|
|
329
|
|
|
|
|
|
|
|
|
330
|
|
|
|
|
|
|
sub set_AAFreqs{ |
|
331
|
2
|
|
|
2
|
1
|
5
|
my ($self,$aafreqs) = @_; |
|
332
|
|
|
|
|
|
|
|
|
333
|
2
|
50
|
33
|
|
|
19
|
if( $aafreqs && ref($aafreqs) =~ /HASH/i ) { |
|
334
|
2
|
|
|
|
|
4
|
foreach my $seqname ( keys %{$aafreqs} ) { |
|
|
2
|
|
|
|
|
9
|
|
|
335
|
13
|
|
|
|
|
26
|
$self->{'_aafreqs'}->{$seqname} = $aafreqs->{$seqname}; |
|
336
|
|
|
|
|
|
|
} |
|
337
|
|
|
|
|
|
|
} |
|
338
|
|
|
|
|
|
|
} |
|
339
|
|
|
|
|
|
|
|
|
340
|
|
|
|
|
|
|
|
|
341
|
|
|
|
|
|
|
sub get_AAFreqs{ |
|
342
|
6
|
|
|
6
|
1
|
3424
|
my ($self,$seqname) = @_; |
|
343
|
6
|
100
|
|
|
|
14
|
if( $seqname ) { |
|
344
|
5
|
|
50
|
|
|
45
|
return $self->{'_aafreqs'}->{$seqname} || {}; |
|
345
|
|
|
|
|
|
|
} else { |
|
346
|
1
|
|
|
|
|
6
|
return $self->{'_aafreqs'}; |
|
347
|
|
|
|
|
|
|
} |
|
348
|
|
|
|
|
|
|
} |
|
349
|
|
|
|
|
|
|
|
|
350
|
|
|
|
|
|
|
|
|
351
|
|
|
|
|
|
|
sub set_NTFreqs{ |
|
352
|
2
|
|
|
2
|
1
|
6
|
my ($self,$freqs) = @_; |
|
353
|
|
|
|
|
|
|
|
|
354
|
2
|
50
|
33
|
|
|
9
|
if( $freqs && ref($freqs) =~ /HASH/i ) { |
|
355
|
2
|
|
|
|
|
4
|
foreach my $seqname ( keys %{$freqs} ) { |
|
|
2
|
|
|
|
|
7
|
|
|
356
|
8
|
|
|
|
|
14
|
$self->{'_ntfreqs'}->{$seqname} = $freqs->{$seqname}; |
|
357
|
|
|
|
|
|
|
} |
|
358
|
|
|
|
|
|
|
} |
|
359
|
|
|
|
|
|
|
} |
|
360
|
|
|
|
|
|
|
|
|
361
|
|
|
|
|
|
|
|
|
362
|
|
|
|
|
|
|
sub get_NTFreqs{ |
|
363
|
1
|
|
|
1
|
1
|
1387
|
my ($self,$seqname) = @_; |
|
364
|
1
|
50
|
|
|
|
3
|
if( $seqname ) { |
|
365
|
0
|
|
0
|
|
|
0
|
return $self->{'_ntfreqs'}->{$seqname} || {}; |
|
366
|
|
|
|
|
|
|
} else { |
|
367
|
1
|
|
|
|
|
3
|
return $self->{'_ntfreqs'}; |
|
368
|
|
|
|
|
|
|
} |
|
369
|
|
|
|
|
|
|
} |
|
370
|
|
|
|
|
|
|
|
|
371
|
|
|
|
|
|
|
|
|
372
|
|
|
|
|
|
|
sub add_stat{ |
|
373
|
11
|
|
|
11
|
1
|
23
|
my ($self,$stat,$value) = @_; |
|
374
|
11
|
50
|
33
|
|
|
47
|
return if( ! defined $stat || !defined $value ); |
|
375
|
11
|
|
|
|
|
22
|
$self->{'_stats'}->{$stat} = $value; |
|
376
|
11
|
|
|
|
|
31
|
return; |
|
377
|
|
|
|
|
|
|
} |
|
378
|
|
|
|
|
|
|
|
|
379
|
|
|
|
|
|
|
|
|
380
|
|
|
|
|
|
|
sub get_stat{ |
|
381
|
8
|
|
|
8
|
1
|
32
|
my ($self,$statname) = @_; |
|
382
|
8
|
|
|
|
|
36
|
return $self->{'_stats'}->{$statname}; |
|
383
|
|
|
|
|
|
|
} |
|
384
|
|
|
|
|
|
|
|
|
385
|
|
|
|
|
|
|
|
|
386
|
|
|
|
|
|
|
sub get_stat_names{ |
|
387
|
1
|
|
|
1
|
1
|
1214
|
my ($self) = @_; |
|
388
|
1
|
50
|
|
|
|
2
|
return keys %{$self->{'_stats'} || {}}; |
|
|
1
|
|
|
|
|
10
|
|
|
389
|
|
|
|
|
|
|
} |
|
390
|
|
|
|
|
|
|
|
|
391
|
|
|
|
|
|
|
|
|
392
|
|
|
|
|
|
|
sub get_AADistMatrix{ |
|
393
|
2
|
|
|
2
|
1
|
5
|
my $self = shift; |
|
394
|
2
|
|
|
|
|
9
|
return $self->{'_AADistMatix'}; |
|
395
|
|
|
|
|
|
|
} |
|
396
|
|
|
|
|
|
|
|
|
397
|
|
|
|
|
|
|
|
|
398
|
|
|
|
|
|
|
sub set_AADistMatrix{ |
|
399
|
2
|
|
|
2
|
1
|
3
|
my ($self,$d) = @_; |
|
400
|
2
|
50
|
33
|
|
|
28
|
if( ! $d || |
|
|
|
|
33
|
|
|
|
|
|
401
|
|
|
|
|
|
|
! ref($d) || |
|
402
|
|
|
|
|
|
|
! $d->isa('Bio::Matrix::PhylipDist') ) { |
|
403
|
0
|
|
|
|
|
0
|
$self->warn("Must provide a valid Bio::Matrix::MatrixI for set_AADistMatrix"); |
|
404
|
|
|
|
|
|
|
} |
|
405
|
2
|
|
|
|
|
5
|
$self->{'_AADistMatix'} = $d; |
|
406
|
2
|
|
|
|
|
4
|
return; |
|
407
|
|
|
|
|
|
|
} |
|
408
|
|
|
|
|
|
|
|
|
409
|
|
|
|
|
|
|
|
|
410
|
|
|
|
|
|
|
sub get_AAMLDistMatrix{ |
|
411
|
1
|
|
|
1
|
1
|
1102
|
my $self = shift; |
|
412
|
1
|
|
|
|
|
3
|
return $self->{'_AAMLDistMatix'}; |
|
413
|
|
|
|
|
|
|
} |
|
414
|
|
|
|
|
|
|
|
|
415
|
|
|
|
|
|
|
|
|
416
|
|
|
|
|
|
|
sub set_AAMLDistMatrix{ |
|
417
|
1
|
|
|
1
|
1
|
2
|
my ($self,$d) = @_; |
|
418
|
1
|
50
|
33
|
|
|
20
|
if( ! $d || |
|
|
|
|
33
|
|
|
|
|
|
419
|
|
|
|
|
|
|
! ref($d) || |
|
420
|
|
|
|
|
|
|
! $d->isa('Bio::Matrix::PhylipDist') ) { |
|
421
|
0
|
|
|
|
|
0
|
$self->warn("Must provide a valid Bio::Matrix::MatrixI for set_AAMLDistMatrix"); |
|
422
|
|
|
|
|
|
|
} |
|
423
|
1
|
|
|
|
|
4
|
$self->{'_AAMLDistMatix'} = $d; |
|
424
|
1
|
|
|
|
|
1
|
return; |
|
425
|
|
|
|
|
|
|
} |
|
426
|
|
|
|
|
|
|
|
|
427
|
|
|
|
|
|
|
|
|
428
|
|
|
|
|
|
|
sub add_NSSite_result{ |
|
429
|
9
|
|
|
9
|
1
|
22
|
my ($self,$model) = @_; |
|
430
|
9
|
50
|
|
|
|
19
|
if( defined $model ) { |
|
431
|
9
|
|
|
|
|
13
|
push @{$self->{'_nssiteresult'}}, $model; |
|
|
9
|
|
|
|
|
19
|
|
|
432
|
|
|
|
|
|
|
} |
|
433
|
9
|
|
|
|
|
19
|
return scalar @{$self->{'_nssiteresult'}}; |
|
|
9
|
|
|
|
|
20
|
|
|
434
|
|
|
|
|
|
|
} |
|
435
|
|
|
|
|
|
|
|
|
436
|
|
|
|
|
|
|
|
|
437
|
|
|
|
|
|
|
sub get_NSSite_results{ |
|
438
|
5
|
|
|
5
|
1
|
5730
|
my ($self) = @_; |
|
439
|
5
|
50
|
|
|
|
9
|
return @{$self->{'_nssiteresult'} || []}; |
|
|
5
|
|
|
|
|
21
|
|
|
440
|
|
|
|
|
|
|
} |
|
441
|
|
|
|
|
|
|
|
|
442
|
|
|
|
|
|
|
|
|
443
|
|
|
|
|
|
|
sub set_CodonFreqs{ |
|
444
|
8
|
|
|
8
|
1
|
18
|
my $self = shift; |
|
445
|
|
|
|
|
|
|
|
|
446
|
8
|
50
|
|
|
|
31
|
return $self->{'_codonfreqs'} = shift if @_; |
|
447
|
0
|
|
|
|
|
0
|
return $self->{'_codonfreqs'}; |
|
448
|
|
|
|
|
|
|
} |
|
449
|
|
|
|
|
|
|
|
|
450
|
|
|
|
|
|
|
|
|
451
|
|
|
|
|
|
|
sub get_CodonFreqs{ |
|
452
|
0
|
|
|
0
|
1
|
0
|
my ($self) = @_; |
|
453
|
0
|
0
|
|
|
|
0
|
return @{$self->{'_codonfreqs'} || []}; |
|
|
0
|
|
|
|
|
0
|
|
|
454
|
|
|
|
|
|
|
} |
|
455
|
|
|
|
|
|
|
|
|
456
|
|
|
|
|
|
|
|
|
457
|
|
|
|
|
|
|
|
|
458
|
|
|
|
|
|
|
sub get_KappaMatrix{ |
|
459
|
1
|
|
|
1
|
1
|
1057
|
my $self = shift; |
|
460
|
1
|
|
|
|
|
2
|
return $self->{'_KappaMatix'}; |
|
461
|
|
|
|
|
|
|
} |
|
462
|
|
|
|
|
|
|
|
|
463
|
|
|
|
|
|
|
|
|
464
|
|
|
|
|
|
|
sub set_KappaMatrix{ |
|
465
|
2
|
|
|
2
|
1
|
4
|
my ($self,$d) = @_; |
|
466
|
2
|
50
|
33
|
|
|
15
|
if( ! $d || |
|
|
|
|
33
|
|
|
|
|
|
467
|
|
|
|
|
|
|
! ref($d) || |
|
468
|
|
|
|
|
|
|
! $d->isa('Bio::Matrix::PhylipDist') ) { |
|
469
|
0
|
|
|
|
|
0
|
$self->warn("Must provide a valid Bio::Matrix::MatrixI for set_NTDistMatrix"); |
|
470
|
|
|
|
|
|
|
} |
|
471
|
2
|
|
|
|
|
4
|
$self->{'_KappaMatix'} = $d; |
|
472
|
2
|
|
|
|
|
4
|
return; |
|
473
|
|
|
|
|
|
|
} |
|
474
|
|
|
|
|
|
|
|
|
475
|
|
|
|
|
|
|
|
|
476
|
|
|
|
|
|
|
|
|
477
|
|
|
|
|
|
|
sub get_AlphaMatrix{ |
|
478
|
1
|
|
|
1
|
1
|
1531
|
my $self = shift; |
|
479
|
1
|
|
|
|
|
3
|
return $self->{'_AlphaMatix'}; |
|
480
|
|
|
|
|
|
|
} |
|
481
|
|
|
|
|
|
|
|
|
482
|
|
|
|
|
|
|
|
|
483
|
|
|
|
|
|
|
sub set_AlphaMatrix{ |
|
484
|
2
|
|
|
2
|
1
|
6
|
my ($self,$d) = @_; |
|
485
|
2
|
50
|
33
|
|
|
14
|
if( ! $d || |
|
|
|
|
33
|
|
|
|
|
|
486
|
|
|
|
|
|
|
! ref($d) || |
|
487
|
|
|
|
|
|
|
! $d->isa('Bio::Matrix::PhylipDist') ) { |
|
488
|
0
|
|
|
|
|
0
|
$self->warn("Must provide a valid Bio::Matrix::MatrixI for set_NTDistMatrix"); |
|
489
|
|
|
|
|
|
|
} |
|
490
|
2
|
|
|
|
|
3
|
$self->{'_AlphaMatix'} = $d; |
|
491
|
2
|
|
|
|
|
3
|
return; |
|
492
|
|
|
|
|
|
|
} |
|
493
|
|
|
|
|
|
|
|
|
494
|
|
|
|
|
|
|
|
|
495
|
|
|
|
|
|
|
sub set_input_parameter{ |
|
496
|
10
|
|
|
10
|
1
|
23
|
my ($self,$p,$v) = @_; |
|
497
|
10
|
50
|
|
|
|
23
|
return unless defined $p; |
|
498
|
10
|
|
|
|
|
41
|
$self->{'_input_parameters'}->{$p} = $v; |
|
499
|
|
|
|
|
|
|
} |
|
500
|
|
|
|
|
|
|
|
|
501
|
|
|
|
|
|
|
|
|
502
|
|
|
|
|
|
|
sub get_input_parameters{ |
|
503
|
0
|
|
|
0
|
1
|
0
|
my ($self) = @_; |
|
504
|
0
|
0
|
|
|
|
0
|
return %{$self->{'_input_parameters'} || {}}; |
|
|
0
|
|
|
|
|
0
|
|
|
505
|
|
|
|
|
|
|
} |
|
506
|
|
|
|
|
|
|
|
|
507
|
|
|
|
|
|
|
|
|
508
|
|
|
|
|
|
|
sub reset_input_parameters{ |
|
509
|
0
|
|
|
0
|
1
|
0
|
my ($self) = @_; |
|
510
|
0
|
|
|
|
|
0
|
$self->{'_input_parameters'} = {}; |
|
511
|
|
|
|
|
|
|
} |
|
512
|
|
|
|
|
|
|
|
|
513
|
|
|
|
|
|
|
|
|
514
|
|
|
|
|
|
|
sub add_rst_seq{ |
|
515
|
20
|
|
|
20
|
1
|
32
|
my ($self,$seq) = @_; |
|
516
|
20
|
50
|
|
|
|
28
|
if( $seq ) { |
|
517
|
20
|
50
|
|
|
|
38
|
unless( $seq->isa("Bio::PrimarySeqI") ) { |
|
518
|
0
|
|
|
|
|
0
|
$self->warn("Must provide a valid Bio::PrimarySeqI to add_rst_seq"); |
|
519
|
0
|
|
|
|
|
0
|
return; |
|
520
|
|
|
|
|
|
|
} |
|
521
|
20
|
|
|
|
|
22
|
push @{$self->{'_rstseqs'}},$seq; |
|
|
20
|
|
|
|
|
37
|
|
|
522
|
|
|
|
|
|
|
} |
|
523
|
|
|
|
|
|
|
|
|
524
|
|
|
|
|
|
|
} |
|
525
|
|
|
|
|
|
|
|
|
526
|
|
|
|
|
|
|
|
|
527
|
|
|
|
|
|
|
sub reset_rst_seqs{ |
|
528
|
20
|
|
|
20
|
1
|
34
|
my ($self) = @_; |
|
529
|
20
|
|
|
|
|
42
|
$self->{'_rstseqs'} = []; |
|
530
|
|
|
|
|
|
|
} |
|
531
|
|
|
|
|
|
|
|
|
532
|
|
|
|
|
|
|
|
|
533
|
|
|
|
|
|
|
sub get_rst_seqs{ |
|
534
|
1
|
|
|
1
|
1
|
1449
|
my ($self) = @_; |
|
535
|
1
|
50
|
|
|
|
2
|
return @{$self->{'_rstseqs'} || []}; |
|
|
1
|
|
|
|
|
6
|
|
|
536
|
|
|
|
|
|
|
} |
|
537
|
|
|
|
|
|
|
|
|
538
|
|
|
|
|
|
|
|
|
539
|
|
|
|
|
|
|
|
|
540
|
|
|
|
|
|
|
sub add_rst_tree{ |
|
541
|
1
|
|
|
1
|
1
|
3
|
my ($self,$tree) = @_; |
|
542
|
1
|
50
|
|
|
|
3
|
if( $tree ) { |
|
543
|
1
|
50
|
|
|
|
4
|
unless( $tree->isa("Bio::Tree::TreeI") ) { |
|
544
|
0
|
|
|
|
|
0
|
$self->warn("Must provide a valid Bio::Tree::TreeI to add_rst_tree not $tree"); |
|
545
|
0
|
|
|
|
|
0
|
return; |
|
546
|
|
|
|
|
|
|
} |
|
547
|
1
|
|
|
|
|
3
|
push @{$self->{'_rsttrees'}},$tree; |
|
|
1
|
|
|
|
|
4
|
|
|
548
|
|
|
|
|
|
|
} |
|
549
|
|
|
|
|
|
|
} |
|
550
|
|
|
|
|
|
|
|
|
551
|
|
|
|
|
|
|
|
|
552
|
|
|
|
|
|
|
sub reset_rst_trees{ |
|
553
|
20
|
|
|
20
|
1
|
46
|
my ($self) = @_; |
|
554
|
20
|
|
|
|
|
44
|
$self->{'_rsttrees'} = []; |
|
555
|
|
|
|
|
|
|
} |
|
556
|
|
|
|
|
|
|
|
|
557
|
|
|
|
|
|
|
|
|
558
|
|
|
|
|
|
|
sub get_rst_trees{ |
|
559
|
1
|
|
|
1
|
1
|
1051
|
my ($self) = @_; |
|
560
|
1
|
50
|
|
|
|
2
|
return @{$self->{'_rsttrees'} || []}; |
|
|
1
|
|
|
|
|
4
|
|
|
561
|
|
|
|
|
|
|
} |
|
562
|
|
|
|
|
|
|
|
|
563
|
|
|
|
|
|
|
|
|
564
|
|
|
|
|
|
|
sub set_rst_persite{ |
|
565
|
1
|
|
|
1
|
1
|
3
|
my $self = shift; |
|
566
|
|
|
|
|
|
|
|
|
567
|
1
|
50
|
|
|
|
5
|
return $self->{'_rstpersite'} = shift if @_; |
|
568
|
0
|
|
|
|
|
0
|
return $self->{'_rstpersite'}; |
|
569
|
|
|
|
|
|
|
} |
|
570
|
|
|
|
|
|
|
|
|
571
|
|
|
|
|
|
|
|
|
572
|
|
|
|
|
|
|
sub get_rst_persite{ |
|
573
|
1
|
|
|
1
|
1
|
3813
|
my ($self) = @_; |
|
574
|
1
|
|
50
|
|
|
7
|
return $self->{'_rstpersite'} || []; |
|
575
|
|
|
|
|
|
|
} |
|
576
|
|
|
|
|
|
|
|
|
577
|
|
|
|
|
|
|
|
|
578
|
|
|
|
|
|
|
|
|
579
|
|
|
|
|
|
|
1; |
|
580
|
|
|
|
|
|
|
|
|
581
|
|
|
|
|
|
|
__END__ |